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An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. 1985.

作者信息

Black J W, Leff P, Shankley N P, Wood J

出版信息

Br J Pharmacol. 2010 Jul;160 Suppl 1(Suppl 1):S54-64. doi: 10.1111/j.1476-5381.2010.00855.x.

DOI:10.1111/j.1476-5381.2010.00855.x
PMID:20590656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2947418/
Abstract
摘要

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THE CHANGES IN RESPONSE AND IN IONIC CONTENT OF SMOOTH MUSCLE PRODUCED BY ACETYLCHOLINE ACTON AND BY CALCIUM DEFICIENCY.乙酰胆碱作用及钙缺乏引起的平滑肌反应和离子含量变化
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Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.累积剂量-反应曲线。II. 离体器官中剂量-反应曲线的制作技术及药物参数的评估
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An action of 5-hydroxytryptamine on adrenaline receptors.5-羟色胺对肾上腺素受体的作用。
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Is Ro 03-7894 an irreversible antagonist at beta-adrenoceptor sites?Ro 03-7894是β-肾上腺素能受体位点的不可逆拮抗剂吗？
Br J Pharmacol. 1984 Jun;82(2):501-8. doi: 10.1111/j.1476-5381.1984.tb10786.x.
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Analysis of dose-response curves and calculation of agonist dissociation constants using a weighted nonlinear curve fitting program.使用加权非线性曲线拟合程序分析剂量反应曲线并计算激动剂解离常数。
J Pharmacol Methods. 1983 Dec;10(4):231-41. doi: 10.1016/0160-5402(83)90017-7.
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Operational models of pharmacological agonism.药理学激动作用的操作模型。
Proc R Soc Lond B Biol Sci. 1983 Dec 22;220(1219):141-62. doi: 10.1098/rspb.1983.0093.
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Use of selective antagonists for determining the types of receptors mediating the actions of 5-hydroxytryptamine and tryptamine in the isolated rabbit aorta.使用选择性拮抗剂确定介导5-羟色胺和色胺对离体兔主动脉作用的受体类型。
J Pharmacol Exp Ther. 1983 Jan;224(1):215-21.
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Noradrenergic component in the vasoconstriction induced by 5-hydroxytryptamine in goat cerebral arteries.5-羟色胺诱导山羊脑动脉血管收缩中的去甲肾上腺素能成分
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