Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S41-52. doi: 10.1111/j.1447-0594.2010.00600.x.
The plasma membrane of eukaryotic cells participates in signal transduction and many other cellular events to maintain the physiological state of cells. In recent decades, much attention has been paid to membrane microdomains, called lipid rafts or membrane rafts, as signaling platforms in the plasma membrane. Lipid rafts are lateral lipid clusters enriched in cholesterol and sphingolipids in which particular molecules are concentrated and participate in membrane-mediated signaling events. Recent studies have shown a close relationship between lipid rafts and the age-associated decline and dysregulation of cellular signaling pathways, such as T-cell receptor signaling and cellular senescence-related signaling. Lipid rafts have also been implicated in senile diseases and in lifestyle-related diseases whose incidences increase with age.
真核细胞的质膜参与信号转导和许多其他细胞事件，以维持细胞的生理状态。在最近几十年中，人们非常关注膜微区，称为脂质筏或膜筏，作为质膜中的信号平台。脂质筏是胆固醇和鞘脂丰富的侧向脂质簇，其中特定分子浓缩并参与膜介导的信号事件。最近的研究表明，脂质筏与与年龄相关的细胞信号通路的衰退和失调密切相关，例如 T 细胞受体信号和与细胞衰老相关的信号。脂质筏也与衰老疾病和与生活方式相关的疾病有关，这些疾病的发病率随着年龄的增长而增加。
