Tokyo Metropolitan Institute of Gerontology, Foundation for Research on Aging and Promotion of Human Welfare, Itabashi-ku, Tokyo, Japan.
Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S80-7. doi: 10.1111/j.1447-0594.2010.00596.x.
Aging is inevitable; however, the molecular mechanism of aging has not been fully elucidated. Investigations into aging are facing difficulties because aging is influenced by complex factors such as circumstances, living habits and genetic background. Recently, a variety of animals, such as Caenorhabditis elegans, Drosophila and mice, that have aberrations in their lifespan, have been investigated and a large number of genes related to aging have been found, one of which is alpha-klotho. The alpha-Klotho mouse (alpha-kl(-/-) mouse), which has a defect of the alpha-klotho gene expression, was established a decade ago. It is of great interest because the alpha-kl(-/-) mouse shows various phenotypes resembling human aging. The relationship between aging and alpha-klotho protein function is gradually becoming clear. This review covers the recent advance in alpha-klotho protein research.
衰老是不可避免的；然而，衰老的分子机制尚未完全阐明。由于衰老受环境、生活习惯和遗传背景等复杂因素的影响，对衰老的研究面临困难。最近，人们研究了各种寿命异常的动物，如秀丽隐杆线虫、果蝇和小鼠，发现了大量与衰老相关的基因，其中之一是α-klotho。α-Klotho 小鼠（alpha-kl(-/-) mouse），其 alpha-klotho 基因表达缺陷，十年前就已建立。它非常有趣，因为 alpha-kl(-/-) 小鼠表现出多种类似于人类衰老的表型。衰老和α-klotho 蛋白功能之间的关系逐渐变得清晰。本文综述了α-klotho 蛋白研究的最新进展。
