脑脊髓液的广谱 16S rRNA PCR 可能不可靠，无法用于术后无菌性脑膜炎的管理。
Broad-range 16S rRNA PCR with cerebrospinal fluid may be unreliable for management of postoperative aseptic meningitis.
机构信息
Department of Internal Medicine, Hôpital Beaujon, 100, Boulevard du Général Leclerc, 92110 Clichy, France.
出版信息
J Clin Microbiol. 2010 Sep;48(9):3331-3. doi: 10.1128/JCM.00008-10. Epub 2010 Jun 30.
Abstract
We previously demonstrated that discontinuing presumptive antibiotic treatment in cases of negative conventional cultures is safe and effective for patients with postoperative aseptic meningitis (PAM). Here, we prospectively investigated 32 patients with postoperative meningitis. All 26 patients with PAM diagnosed on the basis of conventional cultures demonstrated negative 16S rRNA PCR results. Our results suggest that the PCR technique does not change PAM management.
摘要
我们之前的研究表明，对于术后无菌性脑膜炎（PAM）患者，停止常规培养阴性的经验性抗生素治疗是安全有效的。在这里，我们前瞻性研究了 32 例术后脑膜炎患者。所有 26 例经常规培养诊断为 PAM 的患者的 16S rRNA PCR 结果均为阴性。我们的研究结果表明，PCR 技术并不改变 PAM 的治疗策略。
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