一对同卵双胞胎，患重症肌无力症状一致，但胸腺切除术后患系统性红斑狼疮症状出现不一致。

A pair of monozygotic twins who are concordant for myasthenia gravis but became discordant for systemic lupus erythematosus post-thymectomy.

作者信息

Grinlinton F M, Lynch N M, Hart H H

机构信息

Department of Rheumatology, Auckland Hospital, New Zealand.

出版信息

Arthritis Rheum. 1991 Jul;34(7):916-9. doi: 10.1002/art.1780340719.

DOI:10.1002/art.1780340719

PMID:2059238

Abstract

We describe a pair of monozygotic twins who are concordant for myasthenia gravis but discordant for systemic lupus erythematosus (SLE). SLE developed in twin 1 18 years post-thymectomy and has been characterized by recurrent transverse myelitis and optic neuritis. Twin 2 remains well post-thymectomy, except for a skin rash and persistent leukopenia. Both twins have developed autoimmune thyroid disease. We review genetic and environmental factors of importance in the pathogenesis of SLE and discuss the possible role of thymectomy in the etiology of the disease.

摘要

我们描述了一对单卵双胞胎，他们患有重症肌无力，但患系统性红斑狼疮（SLE）的情况不一致。双胞胎1在胸腺切除术后18年患上了SLE，其特征为复发性横贯性脊髓炎和视神经炎。双胞胎2在胸腺切除术后情况良好，只是有皮疹和持续性白细胞减少。这对双胞胎都患上了自身免疫性甲状腺疾病。我们回顾了SLE发病机制中重要的遗传和环境因素，并讨论了胸腺切除术在该病病因学中的可能作用。