Chen W T, Chang D M
Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1996 Mar;57(3):224-7.
Lupus is a mysterious disease without definite etiology and pathogenesis. The heterogeneous clinical manifestation of systemic lupus erythematosus (SLE) increases the delay and difficulty of diagnosis and the complexity of pathogenesis. Even in twins with identical genome and similar environmental milieu, the incidence of concordance for SLE is not high. Identical twins, concordant for SLE with discordance to disease onset and expression, are reported. Besides genetics, multiple factors are responsible for the pathogenesis of SLE.
狼疮是一种病因和发病机制尚不明确的神秘疾病。系统性红斑狼疮（SLE）临床表现的异质性增加了诊断的延迟和难度以及发病机制的复杂性。即使在具有相同基因组和相似环境背景的双胞胎中，SLE的一致性发生率也不高。有报道称，同卵双胞胎患SLE但疾病发作和表现不一致。除了遗传因素外，多种因素也与SLE的发病机制有关。
