速激肽与神经激肽受体在骨髓功能中的作用：神经 - 造血联系
Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link.
作者信息
Klassert Tilman E, Patel Shyam A, Rameshwar Pranela
机构信息
Department of Medicine - Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA.
出版信息
J Receptor Ligand Channel Res. 2010 Apr 1;2010(3):51-61. doi: 10.2147/jrlcr.s6509.
Abstract
After many decades of neuropeptide research, advances in the field of tachykinins have considerably increased and shown their implications in several physiological processes. In this review we focus on the role of the tachykinins in the regulation of hematopoietic functions. Evidence has shown that neural control of this process is emerging as a significant category in hematopoietic modulation. In the context of this regulation, we discuss the existence of a complex network involving the neurokinin receptors, tachykinins and cytokines. This network is tightly regulated by each of its components.
摘要
经过数十年的神经肽研究，速激肽领域取得了显著进展，并显示出它们在多个生理过程中的作用。在本综述中，我们重点关注速激肽在造血功能调节中的作用。有证据表明，这一过程的神经控制正成为造血调节中的一个重要类别。在这种调节的背景下，我们讨论了一个涉及神经激肽受体、速激肽和细胞因子的复杂网络的存在。这个网络受到其每个组成部分的严格调控。
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