Gotch F M, Hovell R, Delchambre M, Silvera P, McMichael A J
Molecular Immunology Group, John Radcliffe Hospital, Oxford, UK.
AIDS. 1991 Mar;5(3):317-20. doi: 10.1097/00002030-199103000-00012.
Simian immunodeficiency virus (SIV) gag-specific major histocompatibility complex (MHC)-restricted cytotoxic T-lymphocyte (CTL) activity was elicited in four out of six cynomolgus macaques after two immunizations with SIV gag recombinant vaccinia virus (rVV). No activity could be seen in three out of three non-immunized control animals. Low levels of anti-gag antibody were also seen in the same four responding animals. Virus-specific, MHC-restricted CTL are thought to give some protection and to assist in recovery in viral infection, and the induction of such CTL following vaccination with a single viral protein should act as an encouragement to those proposing similar vaccination studies in man.
用猿猴免疫缺陷病毒（SIV）gag重组痘苗病毒（rVV）对6只食蟹猴进行两次免疫后，6只中有4只引发了猿猴免疫缺陷病毒（SIV）gag特异性主要组织相容性复合体（MHC）限制性细胞毒性T淋巴细胞（CTL）活性。3只未免疫的对照动物中无一出现活性。在同样4只产生反应的动物中也检测到低水平的抗gag抗体。病毒特异性、MHC限制性CTL被认为可提供一定保护并有助于病毒感染后的恢复，用单一病毒蛋白进行疫苗接种后诱导出此类CTL应会激励那些提议在人体中开展类似疫苗接种研究的人员。
