新型的、一锅法、三组分合成吲哚-3-基取代螺环氧化吲哚衍生物的路线。
Novel, one-pot, three-component route to indol-3-yl substituted spirooxindole derivatives.
作者信息
Chen Tao, Xu Xiao-Ping, Ji Shun-Jun
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
出版信息
J Comb Chem. 2010 Sep 13;12(5):659-63. doi: 10.1021/cc100064c.
PMID:20593846
Abstract
A simple and efficient approach to the synthesis of a novel series of polysubstituted 6'-(1H-indol-3-yl)-1',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2-one derivatives in high yields was developed from a one-pot, three-component reaction of 3-cyanoacetyl indoles, isatins, and 1H-pyrazol-5-amines in H(2)O/HOAc.
摘要
通过3-氰基乙酰吲哚、异吲哚酮和1H-吡唑-5-胺在水/醋酸中的一锅三组分反应，开发了一种简单有效的方法来高产率合成一系列新型多取代的6'-(1H-吲哚-3-基)-1',7'-二氢螺[吲哚啉-3,4'-吡唑并[3,4-b]吡啶]-2-酮衍生物。
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