Pretorius Etheresia, Oberholzer Hester Magdalena, van der Spuy Wendy Jeannette, Meiring Johannes Henricus
Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Ultrastruct Pathol. 2010 Aug;34(4):236-9. doi: 10.3109/01913121003743716.
Smoking impacts on hemostasis and coagulation physiology is affected. Although this is well known, no previous research is available on the impact of smoking on fibrin network morphology. Here the authors show that smoking causes the fibrin network to have a netlike appearance in some areas, as well as areas where thick plaques are present. They argue that even in occasional smokers, fibrin, in the presence of thrombin, forms thickened areas that might be the cause of a thrombotic event such as stroke. Furthermore, it seems as if smoking impacts immediately on the fibrin architecture, and this therefore does not happen only over an extended period of smoking exposure. This information is important, particularly for women with additional risk during contraceptive use and pregnancy. The authors propose the term sticky fibrin phenomenon and suggest that this is the cause for thrombotic events during smoking.
吸烟对止血和凝血生理产生影响。尽管这一点众所周知，但此前尚无关于吸烟对纤维蛋白网络形态影响的研究。在此，作者表明吸烟会导致纤维蛋白网络在某些区域呈现出网状外观，以及出现厚斑块的区域。他们认为，即使是偶尔吸烟的人，在凝血酶存在的情况下，纤维蛋白也会形成增厚区域，这可能是导致中风等血栓形成事件的原因。此外，吸烟似乎会立即影响纤维蛋白结构，因此并非仅在长期吸烟暴露后才会发生这种情况。这一信息很重要，特别是对于在使用避孕药和怀孕期间有额外风险的女性。作者提出了“粘性纤维蛋白现象”这一术语，并认为这是吸烟期间血栓形成事件的原因。
