Mimouni-Bloch Aviva, Schneider Carolina, Politi Keren Elishkevitz, Konen Osnat, Gothelf Doron, Stark Batia, Yaniv Isaac, Shuper Avinoam
Pediatric Neurology and Developmental Unit, Loewenstein Rehabilitation Hospital, Raanana, Israel.
J Child Neurol. 2010 Jul;25(7):884-7. doi: 10.1177/0883073809351317.
The spectrum of the possible manifestations of Langerhans' cell histiocytosis in children is very wide, ranging from a simple rash to major multiorgan disease. There may be hypothalamic and pituitary dysfunction or more global neurological and neuropsychiatric manifestations when the central nervous system is affected. The cerebellum is preferentially affected for yet undetermined reasons. The clinical presentation includes motor dysfunction as well as cognitive, behavioral, and psychiatric expression of the ongoing neurodegeneration. We report a young patient with Langerhans' cell histiocytosis who underwent an unusual course of psychiatric deterioration.
儿童朗格汉斯细胞组织细胞增多症可能的表现范围非常广泛，从简单的皮疹到严重的多器官疾病。当累及中枢神经系统时，可能会出现下丘脑和垂体功能障碍或更广泛的神经及神经精神表现。小脑更易受到影响，原因尚不明。临床表现包括运动功能障碍以及正在进行的神经变性的认知、行为和精神方面的表现。我们报告了一名患有朗格汉斯细胞组织细胞增多症的年轻患者，其经历了不寻常的精神状态恶化过程。
