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单中心体外膜肺氧合转运的经验:一项描述性研究。

Single-institution experience with interhospital extracorporeal membrane oxygenation transport: A descriptive study.

机构信息

Department of Pediatrics, University of Arkansas for Medical Sciences College of Medicine, Little Rock, AR, USA.

出版信息

Pediatr Crit Care Med. 2010 Jul;11(4):509-13. doi: 10.1097/PCC.0b013e3181c515ca.

Abstract

OBJECTIVE

Patients with refractory cardiopulmonary failure may benefit from extracorporeal membrane oxygenation, but extracorporeal membrane oxygenation is not available in all medical centers. We report our institution's nearly 20-yr experience with interhospital extracorporeal membrane oxygenation transport.

DESIGN

Retrospective review.

SETTING

Quaternary care children's hospital.

PATIENTS

All patients undergoing interhospital extracorporeal membrane oxygenation transport by the Arkansas Children's Hospital extracorporeal membrane oxygenation team.

INTERVENTIONS

Data (age, weight, diagnosis, extracorporeal membrane oxygenation course, hospital course, mode of transport, and outcome) were obtained and compared with the most recent Extracorporeal Life Support Organization Registry report.

RESULTS

Interhospital extracorporeal membrane oxygenation transport was provided to 112 patients from 1990 to 2008. Eight were transferred between outside facilities (TAXI group); 104 were transported to our hospital (RETURN group). Transport was by helicopter (75%), ground (12.5%), and fixed wing (12.5%). No patient died during transport. Indications for extracorporeal membrane oxygenation in RETURN patients were cardiac failure in 46% (48 of 104), neonatal respiratory failure in 34% (35 of 104), and other respiratory failure in 20% (21 of 104). Overall survival from extracorporeal membrane oxygenation for the RETURN group was 71% (74 of 104); overall survival to discharge was 58% (61 of 104). Patients with cardiac failure had a 46% (22 of 48) rate of survival to discharge. Neonates with respiratory failure had an 80% (28 of 35) rate of survival to discharge. Other patients with respiratory failure had a 62% (13 of 21) rate of survival to discharge. None of these survival rates were statistically different from survival rates for in-house extracorporeal membrane oxygenation patients or for survival rates reported in the international Extracorporeal Life Support Organization Registry (p > .1 for all comparisons).

CONCLUSIONS

Outcomes of patients transported by an experienced extracorporeal membrane oxygenation team to a busy extracorporeal membrane oxygenation center are very comparable to outcomes of nontransported extracorporeal membrane oxygenation patients as reported in the Extracorporeal Life Support Organization registry. As has been previously reported, interhospital extracorporeal membrane oxygenation transport is feasible and can be accomplished safely. Other experienced extracorporeal membrane oxygenation centers may want to consider developing interhospital extracorporeal membrane oxygenation transport capabilities to better serve patients in different geographic regions.

摘要

目的

心肺衰竭的难治性患者可能受益于体外膜氧合,但并非所有医疗中心都提供体外膜氧合。我们报告了本机构近 20 年来在医院间体外膜氧合转运方面的经验。

设计

回顾性研究。

地点

四级保健儿童医院。

患者

所有接受阿肯色儿童医院体外膜氧合小组医院间体外膜氧合转运的患者。

干预措施

获取数据(年龄、体重、诊断、体外膜氧合过程、医院过程、转运方式和结果),并与最近的体外生命支持组织登记报告进行比较。

结果

1990 年至 2008 年,112 名患者进行了医院间体外膜氧合转运。8 名患者在外部设施之间转移(TAXI 组);104 名患者被转运至我院(RETURN 组)。转运方式为直升机(75%)、地面(12.5%)和固定翼(12.5%)。没有患者在转运过程中死亡。RETURN 组患者体外膜氧合的指征为心力衰竭 46%(48/104)、新生儿呼吸衰竭 34%(35/104)和其他呼吸衰竭 20%(21/104)。RETURN 组体外膜氧合总存活率为 71%(74/104);出院总存活率为 58%(61/104)。心力衰竭患者的出院存活率为 46%(22/48)。呼吸衰竭的新生儿出院存活率为 80%(28/35)。其他呼吸衰竭患者的出院存活率为 62%(13/21)。这些存活率与院内体外膜氧合患者的存活率或国际体外生命支持组织登记处报告的存活率均无统计学差异(所有比较均为 p>.1)。

结论

由经验丰富的体外膜氧合小组转运至繁忙的体外膜氧合中心的患者的治疗结果与体外生命支持组织登记处报告的非转运体外膜氧合患者的治疗结果非常相似。正如之前报道的,医院间体外膜氧合转运是可行的,并且可以安全完成。其他有经验的体外膜氧合中心可能希望考虑发展医院间体外膜氧合转运能力,以便更好地为不同地理区域的患者服务。

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