农药使用与农业健康研究中农场妇女心肌梗死发病率。
Pesticide use and myocardial infarction incidence among farm women in the agricultural health study.
机构信息
School of Public Health, University of Nevada Reno, Reno, Nev, USA.
出版信息
J Occup Environ Med. 2010 Jul;52(7):693-7. doi: 10.1097/JOM.0b013e3181e66d25.
Abstract
OBJECTIVE
To evaluate the relationship between pesticide use and myocardial infarction (MI) among farm women.
BACKGROUND
Little is known about the potential association between pesticide use and cardiovascular outcomes.
METHODS
We used logistic regression to evaluate pesticide use and self-reported incident nonfatal MI among women in the Agricultural Health Study.
RESULTS
Of those MI-free at enrollment (n = 22,425), 168 reported an MI after enrollment. We saw no association with pesticide use overall. Six of 27 individual pesticides evaluated were significantly associated with nonfatal MI, including chlorpyrifos, coumaphos, carbofuran, metalaxyl, pendimethalin, and trifluralin, which all had odds ratios >1.7. These chemicals were used by <10% of the cases, and their use was correlated, making it difficult to attribute the risk elevation to a specific pesticide.
CONCLUSION
Pesticides may contribute to MI risk among farm women.
摘要
目的
评估农药使用与农场女性心肌梗死（MI）之间的关系。
背景
关于农药使用与心血管结局之间潜在关联的了解甚少。
方法
我们使用逻辑回归评估了农业健康研究中女性的农药使用与自我报告的非致命性 MI 事件之间的关系。
结果
在无 MI 的入组者（n=22425）中，有 168 人在入组后报告了 MI。我们没有发现总体上农药使用与 MI 之间存在关联。评估的 27 种单独农药中有 6 种与非致命性 MI 显著相关，包括毒死蜱、氯菊酯、克百威、甲霜灵、二甲戊灵和氟乐灵，其比值比均>1.7。这些化学物质仅被<10%的病例使用，且它们的使用相互关联，使得难以将风险升高归因于特定的农药。
结论
农药可能会增加农场女性的 MI 风险。
相似文献
1
Pesticide use and myocardial infarction incidence among farm women in the agricultural health study.
J Occup Environ Med. 2010 Jul;52(7):693-7. doi: 10.1097/JOM.0b013e3181e66d25.
2
Pesticides and myocardial infarction incidence and mortality among male pesticide applicators in the Agricultural Health Study.
Am J Epidemiol. 2009 Oct 1;170(7):892-900. doi: 10.1093/aje/kwp214. Epub 2009 Aug 21.
3
Pesticide Use and Incident Hypothyroidism in Pesticide Applicators in the Agricultural Health Study.
Environ Health Perspect. 2018 Sep;126(9):97008. doi: 10.1289/EHP3194.
4
Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study.
Environ Health Perspect. 2017 Jul 19;125(7):077013. doi: 10.1289/EHP793.
5
Rhinitis associated with pesticide use among private pesticide applicators in the agricultural health study.
J Toxicol Environ Health A. 2010;73(20):1382-93. doi: 10.1080/15287394.2010.497443.
6
Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study.
Environ Health Perspect. 2020 Jun;128(6):67011. doi: 10.1289/EHP6334. Epub 2020 Jun 12.
7
Pesticide exposure and incident thyroid cancer among male pesticide applicators in agricultural health study.
Environ Int. 2021 Jan;146:106187. doi: 10.1016/j.envint.2020.106187. Epub 2020 Oct 27.
8
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.
Environ Health Perspect. 2014 Sep;122(9):984-91. doi: 10.1289/ehp.1307450. Epub 2014 Jun 6.
9
Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study.
J Natl Cancer Inst. 2004 Dec 1;96(23):1781-9. doi: 10.1093/jnci/djh324.
10
Pesticide exposure and risk of aggressive prostate cancer among private pesticide applicators.
Environ Health. 2020 Mar 5;19(1):30. doi: 10.1186/s12940-020-00583-0.
引用本文的文献
1
Is Farming a Risk Occupation for Cardio-cerebrovascular Diseases? A Scoping Review on Cardio-cerebrovascular Disease Risk in Farmers.
J Prev Med Public Health. 2024 Nov;57(6):521-529. doi: 10.3961/jpmph.24.302. Epub 2024 Aug 23.
2
Residential proximity to agricultural pesticide use and cardiovascular disease risk factors among adult Latina women in California's Salinas Valley.
Am J Epidemiol. 2024 Nov 4;193(11):1583-1591. doi: 10.1093/aje/kwae118.
3
Investigating the relationship between non-occupational pesticide exposure and metabolomic biomarkers.
Front Public Health. 2023 Oct 11;11:1248609. doi: 10.3389/fpubh.2023.1248609. eCollection 2023.
4
Pollutants, including Organophosphorus and Organochloride Pesticides, May Increase the Risk of Cardiac Remodeling and Atrial Fibrillation: A Narrative Review.
Biomedicines. 2023 Aug 30;11(9):2427. doi: 10.3390/biomedicines11092427.
5
Hematological indices as indicators of inflammation induced by exposure to pesticides.
Environ Sci Pollut Res Int. 2023 Feb;30(7):19466-19476. doi: 10.1007/s11356-022-23509-4. Epub 2022 Oct 14.
6
Case Report: Effective Treatment for Acute Chlorpyrifos Poisoning Complicated by a Non-ST-Segment Elevation Myocardial Infarction.
Front Cardiovasc Med. 2021 Apr 30;8:623708. doi: 10.3389/fcvm.2021.623708. eCollection 2021.
7
Social and environmental risks as contributors to the clinical course of heart failure.
Heart Fail Rev. 2022 Jul;27(4):1001-1016. doi: 10.1007/s10741-021-10116-7. Epub 2021 May 4.
8
Unusual aetiology of a type 2 myocardial infarction: a case-based review.
Arh Hig Rada Toksikol. 2021 Mar 30;72(1):80-87. doi: 10.2478/aiht-2021-72-3502. Print 2021 Mar 1.
9
Occupational Exposures and Cardiac Structure and Function: ECHO-SOL (Echocardiographic Study of Latinos).
J Am Heart Assoc. 2020 Sep;9(17):e016122. doi: 10.1161/JAHA.120.016122. Epub 2020 Aug 26.
10
Association Between Occupational Exposure to Pesticides and Cardiovascular Disease Incidence: The Kuakini Honolulu Heart Program.
J Am Heart Assoc. 2019 Oct;8(19):e012569. doi: 10.1161/JAHA.119.012569. Epub 2019 Sep 25.
本文引用的文献
1
Pesticides and myocardial infarction incidence and mortality among male pesticide applicators in the Agricultural Health Study.
Am J Epidemiol. 2009 Oct 1;170(7):892-900. doi: 10.1093/aje/kwp214. Epub 2009 Aug 21.
2
Cardiac abnormalities in acute organophosphate poisoning.
Clin Toxicol (Phila). 2009 Mar;47(3):230-5. doi: 10.1080/15563650902724813.
3
Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.
J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12. doi: 10.1210/jc.2006-2190. Epub 2007 Apr 24.
4
Proportionate mortality among current and former members of the United Farm Workers of America, AFL-CIO, in California 1973-2000.
J Agromedicine. 2006;11(1):39-48. doi: 10.1300/J096v11n01_05.
5
Mortality from ischemic heart disease and diabetes mellitus (type 2) in four U.S. wheat-producing states: a hypothesis-generating study.
Environ Health Perspect. 2006 Feb;114(2):186-93. doi: 10.1289/ehp.8352.
6
Mortality among participants in the agricultural health study.
Ann Epidemiol. 2005 Apr;15(4):279-85. doi: 10.1016/j.annepidem.2004.08.008.
7
Mortality among a cohort of female farm residents in New York State.
Arch Environ Health. 2003 Oct;58(10):642-8. doi: 10.3200/AEOH.58.10.642-648.
8
Postal questionnaires identified hospitalizations for self-reported acute myocardial infarction.
J Clin Epidemiol. 2004 Sep;57(9):989-92. doi: 10.1016/j.jclinepi.2004.01.016.
9
Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey.
Circulation. 2004 Jan 6;109(1):42-6. doi: 10.1161/01.CIR.0000108926.04022.0C. Epub 2003 Dec 15.
10
National Health Interview Survey mortality among US farmers and pesticide applicators.
Am J Ind Med. 2003 Feb;43(2):227-33. doi: 10.1002/ajim.10162.
Zotero 插件