Boston University, Department of Mechanical Engineering, 110 Cummington Street, Boston, Massachusetts 02215, USA.
Opt Lett. 2010 Jul 1;35(13):2127-9. doi: 10.1364/OL.35.002127.
A technique to enhance the photoacoustic emissions from laser-heated nanoparticles is presented. Gold nanoparticle-doped phantoms are subjected to pulsed optical and ultrasound fields, resulting in bubble formation and collapse and producing strong acoustic emissions. The applied ultrasound field allows for cavitation at lower laser fluences than using light alone. The acoustic emission associated with bubble collapse well exceeds the direct photoacoustic response and is used to image a nanoparticle-doped region in a tissue phantom. The strong acoustic emission and low-threshold fluence associated with ultrasound-assisted cavitation make the technique well suited for nanoparticle-targeted biological imaging and tissue therapy.
本文提出了一种增强激光加热纳米颗粒光声发射的技术。金纳米粒子掺杂的体模受到脉冲光和超声场的作用，导致气泡的形成和坍塌，并产生强烈的声发射。与单独使用光相比，施加的超声场允许在更低的激光能密度下空化。与气泡坍塌相关的声发射远远超过直接光声响应，并用于对组织体模中的纳米粒子掺杂区域进行成像。与超声辅助空化相关的强声发射和低阈值能密度使该技术非常适合用于纳米颗粒靶向的生物成像和组织治疗。
