内部灌注心肌细胞中肌膜下钠离子浓度的变化
Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells.
作者信息
Bielen F V, Glitsch H G, Verdonck F
机构信息
Interdisciplinary Research Centre, Catholic University of Leuven, Kortrijk, Belgium.
出版信息
Biochim Biophys Acta. 1991 Jun 18;1065(2):269-71. doi: 10.1016/0005-2736(91)90239-5.
PMID:2059657
Abstract
Transients of Na+/K+ pump and of Na+/Ca2+ exchange current occur during whole-cell recording from cardiac cells upon quick changes of active Na+ efflux. The transients reflect a temporary loss of control of the subsarcolemmal Na+ concentration. Even in the steady state the control is not complete is certain cells. Quantitative studies on ion transport by whole-cell recording are meaningful only if an adequate control of the submembranal ionic composition is demonstrated.
摘要
在对心脏细胞进行全细胞记录时，当主动钠外流快速变化时，会出现钠钾泵和钠钙交换电流的瞬变现象。这些瞬变反映了肌膜下钠浓度暂时失去控制。即使在稳态下，某些细胞中的控制也并不完全。只有在证明对膜下离子组成有充分控制的情况下，通过全细胞记录对离子转运进行定量研究才有意义。
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