Fuss M, Pepersack T, Corvilain J, Bergmann P, Willems D, Simon J, Body J J
Université Libre de Bruxelles, Belgium.
Bone Miner. 1991 May;13(2):131-7. doi: 10.1016/0169-6009(91)90080-j.
Circulating concentrations of calcitonin (CT) have been found high in idiopathic renal calcium stone formers (RSF). It has been postulated that this could result from increased serum calcium concentrations following calcium-containing meals. To verify this hypothesis, 15 male idiopathic RSF and 15 male normal subjects underwent plasma CT measurements, following an extraction-concentration technique (exCT), in basal state and during an oral calcium load test. Most RSF exhibited increased excretion of calcium following oral calcium loading, suggesting overabsorption of calcium, but serum calcium did not increase more in RSF than in normal subjects. Basal plasma exCT concentrations were normal in RSF. ExCT plasma concentrations following calcium loading, and the area under the curve of exCT levels, tended to be higher in RSF than in normal subjects, but not significantly. Our results thus do not support the hypothesis that increased plasma CT levels in RSF result from increased serum calcium concentrations following calcium-containing meals.
已发现特发性肾钙结石形成者（RSF）的循环降钙素（CT）浓度较高。据推测，这可能是由于摄入含钙食物后血清钙浓度升高所致。为验证这一假设，15名男性特发性RSF患者和15名男性正常受试者在基础状态下以及口服钙负荷试验期间，采用提取浓缩技术（exCT）进行了血浆CT测量。大多数RSF患者在口服钙负荷后钙排泄增加，提示钙吸收过多，但RSF患者的血清钙升高幅度并不比正常受试者更大。RSF患者的基础血浆exCT浓度正常。钙负荷后RSF患者的exCT血浆浓度以及exCT水平曲线下面积往往高于正常受试者，但差异无统计学意义。因此，我们的结果不支持RSF患者血浆CT水平升高是由于摄入含钙食物后血清钙浓度升高这一假设。
