Shetty Smitha R, Prabhu Sudeendra
SDM College of Dental Sciences, Dharwad, India.
Head Neck Pathol. 2009 Mar;3(1):54-8. doi: 10.1007/s12105-009-0105-6. Epub 2009 Feb 15.
Angiomatosis is a diffuse vascular lesion which involves a large segment of the body in a contiguous fashion involving multiple tissues (e.g. subcutis, muscle, bone, adipose tissue etc.) in different planes. Such lesions usually present in the first two decades of life with female predilection and are commonly seen in lower extremities. It clinically mimics hemangioma or vascular malformation and its surgical removal is difficult because of its infiltrative nature and thus has high recurrence rate (90%). Therefore a precise histopathological diagnosis of angiomatosis is important to achieve a curative resection. Histopathologically it consists of proliferating blood vessels of varying caliber, infiltrating into the soft tissues. Proliferating capillaries are seen within or adjacent to major vessels. Few cases are reported in head and neck region. This article highlights three unusual cases of angiomatosis reported as benign lesions, in rare sites such as the malar region (predominantly infiltrating the adipose tissue), within the masseter (predominantly infiltrating the muscle) and in the mandible (infiltrating the bone). Histopathological differential diagnosis is also discussed.
血管母细胞瘤病是一种弥漫性血管病变，它以连续的方式累及身体的一大段区域，涉及不同平面的多个组织（如皮下组织、肌肉、骨骼、脂肪组织等）。此类病变通常在生命的前二十年出现，女性更为多见，常见于下肢。其临床表现类似血管瘤或血管畸形，由于具有浸润性，手术切除困难，因此复发率很高（90%）。所以，对血管母细胞瘤病进行精确的组织病理学诊断对于实现根治性切除很重要。组织病理学上，它由不同管径的增生血管组成，浸润至软组织中。在主要血管内或其附近可见增生的毛细血管。头颈部区域报道的病例较少。本文重点介绍了三例不寻常的血管母细胞瘤病病例，这些病例被报告为良性病变，发生在罕见部位，如颧部区域（主要浸润脂肪组织）、咬肌内（主要浸润肌肉）和下颌骨（浸润骨骼）。文中还讨论了组织病理学鉴别诊断。
