Department of Internal Medicine, Istanbul University Cardiology Institute, Istanbul University, Istanbul, Turkey.
Clin Transplant. 2011 May-Jun;25(3):368-74. doi: 10.1111/j.1399-0012.2010.01244.x. Epub 2010 Jun 27.
Serum uric acid (UA) level as a significant and independent risk factor for cardiovascular disease, and the link between this marker and left ventricular hypertrophy (LVH) in renal transplant recipients remains to be clarified.
A total of 141 renal transplant recipients (83 men), between ages of 18 and 69 (mean age 37 ± 11), were included in this single center study. In addition to demographic, clinical, and laboratory parameters, serum UA concentrations were evaluated. LVH was determined by two-dimensional and M-mode echocardiography.
Serum UA levels were significantly higher (6.14 ± 1.15 mg/dL) in patients with LVH (n = 54) when compared to patients (n = 87) who did not have this abnormality (5.29 ± 1.43 mg/dL) (p = 0.006). Serum UA levels were significantly correlated with septal wall thickness, LV posterior wall thickness, LV mass index (LVMI), and pulmonary arterial pressure. Multiple linear regression analysis revealed that UA predicted LVMI (r(2) = 0.150, β = 0.369, p = 0.001). However, serum creatinine (β = 0.060, p = 0.593) and age (β = 0.146, p = 0.175) were not predictors of LVMI.
High serum UA levels are associated with LVH in renal transplant recipients, which underlines the importance of treating hyperuricemia.
血清尿酸（UA）水平是心血管疾病的一个重要且独立的危险因素，该标志物与肾移植受者左心室肥厚（LVH）之间的联系仍需阐明。
本单中心研究共纳入 141 例肾移植受者（83 例男性），年龄 18 至 69 岁（平均年龄 37±11 岁）。除了人口统计学、临床和实验室参数外，还评估了血清 UA 浓度。LVH 通过二维和 M 型超声心动图确定。
与无 LVH 异常的患者（n=87）相比，患有 LVH 的患者（n=54）的血清 UA 水平明显更高（6.14±1.15mg/dL）（p=0.006）。血清 UA 水平与室间隔厚度、LV 后壁厚度、LV 质量指数（LVMI）和肺动脉压显著相关。多元线性回归分析显示 UA 可预测 LVMI（r²=0.150，β=0.369，p=0.001）。然而，血清肌酐（β=0.060，p=0.593）和年龄（β=0.146，p=0.175）并非 LVMI 的预测因素。
肾移植受者的血清 UA 水平升高与 LVH 相关，这强调了治疗高尿酸血症的重要性。
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