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完全性房室间隔缺损:可调式装置改善肺动脉环缩术的预后。

Complete atrioventricular septal defect: outcome of pulmonary artery banding improved by adjustable device.

机构信息

Cardiac Unit, Alder Hey Children NHS Foundation Trust, Liverpool, United Kingdom.

出版信息

J Thorac Cardiovasc Surg. 2011 Jan;141(1):179-82. doi: 10.1016/j.jtcvs.2010.03.047. Epub 2010 Jul 2.

Abstract

OBJECTIVE

We sought to evaluate pulmonary artery banding in infants with complete atrioventricular septal defects.

METHODS

From 2000 to 2009, 20 infants with complete atrioventricular septal defects underwent pulmonary artery banding because of unsuitable anatomy (unbalanced ventricles, associated lesions, or both) or clinical condition (infection, chronic lung disease, or noncardiac malformation). Patients were divided into 2 groups: the conventional PAB group (n = 13 [65%]; mean age, 74 ± 56 days [range, 6-187 days]; mean weight, 3.3 ± 1.1 kg [range, 2.1-5.8 kg]) and the FloWatch-PAB group (n = 7 [35%]; mean age, 111 ± 40 days [range, 81-187 days]; mean weight, 4.3 ± 1.2 kg [range, 3.2-6.1 kg]). There was no statistical difference in age or weight. Preoperative mechanical ventilation was required in 3 (23%) of 13 infants in the conventional PAB group and 5 (71%) of 7 infants in the FloWatch-PAB group (P < .05).

RESULTS

Ten (77%) of 13 infants in the conventional PAB group died versus 0 (0%) of 7 infants in the FloWatch-PAB group (P < .001). Sternal closure was delayed in 6 (46%) of 13 infants in the conventional PAB group and 0 (0%) of 7 infants in the FloWatch-PAB group (P < .05). The mean duration of mechanical ventilation, intensive care unit stay, and hospital stay was significantly longer (P < .05) in the conventional PAB group than in the FloWatch-PAB group (21 ± 17 days [range, 4-61 days] vs 3 ± 2 days [range, 1-8 days], 22 ± 18 days [range, 5-61 days] vs 7 ± 6 days [range, 2-21 days], and 54 ± 12 days [range, 40-71 days] vs 29 ± 25 days [range, 9-81 days], respectively). Left atrioventricular valve regurgitation increased (mild to moderate) in 2 infants in the conventional PAB group and decreased (severe to moderate) in 2 infants in the FloWatch-PAB group. Six of 10 survivors (1 in the conventional PAB group and 5 in the FloWatch-PAB group) underwent pulmonary artery debanding and repair after a median interval of 125 days (range, 34-871 days); 4 of 10 are awaiting repair.

CONCLUSIONS

In selected patients with complete atrioventricular septal defects, pulmonary artery banding followed by late repair is a viable alternative strategy. In our study the FloWatch-PAB device resulted in improved survival and made later repair possible in a better clinical state.

摘要

目的

我们旨在评估肺动脉环缩术在完全性房室间隔缺损婴儿中的应用效果。

方法

2000 年至 2009 年,20 例因解剖结构不适合(心室不平衡、合并病变或两者兼有)或临床情况(感染、慢性肺部疾病或非心脏畸形)而接受肺动脉环缩术的完全性房室间隔缺损婴儿被纳入研究。患者被分为两组:传统肺动脉环缩术(PAB)组(n = 13 [65%];平均年龄 74 ± 56 天[范围 6-187 天];平均体重 3.3 ± 1.1 kg[范围 2.1-5.8 kg])和 FloWatch-PAB 组(n = 7 [35%];平均年龄 111 ± 40 天[范围 81-187 天];平均体重 4.3 ± 1.2 kg[范围 3.2-6.1 kg])。两组在年龄和体重方面无统计学差异。传统 PAB 组中有 3 例(23%)婴儿在术前需要机械通气,而 FloWatch-PAB 组中则有 5 例(71%)婴儿需要机械通气(P <.05)。

结果

传统 PAB 组中有 10 例(77%)婴儿死亡,而 FloWatch-PAB 组中无一例死亡(P <.001)。传统 PAB 组中有 6 例(46%)婴儿出现胸骨愈合延迟,而 FloWatch-PAB 组中无此情况(P <.05)。传统 PAB 组婴儿的机械通气、重症监护病房和住院时间明显长于 FloWatch-PAB 组(P <.05),分别为 21 ± 17 天[范围 4-61 天]比 3 ± 2 天[范围 1-8 天],22 ± 18 天[范围 5-61 天]比 7 ± 6 天[范围 2-21 天],54 ± 12 天[范围 40-71 天]比 29 ± 25 天[范围 9-81 天]。传统 PAB 组中有 2 例婴儿左房室瓣反流增加(轻度至中度),FloWatch-PAB 组中有 2 例婴儿反流减少(重度至中度)。10 例幸存者中有 6 例(传统 PAB 组 1 例,FloWatch-PAB 组 5 例)在中位间隔 125 天(范围 34-871 天)后接受肺动脉带松解和修复;10 例中 4 例仍在等待修复。

结论

在特定的完全性房室间隔缺损患者中,肺动脉环缩术联合后期修复是一种可行的替代策略。在我们的研究中,FloWatch-PAB 装置提高了存活率,并使后期修复在更好的临床状态下成为可能。

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