Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
Acad Radiol. 2010 Aug;17(8):1050-6. doi: 10.1016/j.acra.2010.03.017.
The aim of this study was to assess the feasibility of dynamic contrast-enhanced ultra-high-field breast imaging at 7 Tesla.
A total of 15 subjects, including 5 patients with histologically proven breast cancer, were examined on a 7 Tesla whole-body magnetic resonance imaging system using a unilateral linearly polarized single-loop coil. Subjects were placed in prone position on a biopsy support system, with the coil placed directly below the region of interest. The examination protocol included the following sequences: 1) T2-weighted turbo spin echo sequence; 2) six dynamic T1-weighted spoiled gradient-echo sequences; and 3) subtraction imaging.
Contrast-enhanced T1-weighted imaging at 7 Tesla could be obtained at high spatial resolution with short acquisition times, providing good image accuracy and a conclusively good delineation of small anatomical and pathological structures. T2-weighted imaging could be obtained with high spatial resolution at adequate acquisition times. Because of coil limitations, four high-field magnetic resonance examinations showed decreased diagnostic value.
This first scientific approach of dynamic contrast-enhanced breast magnetic resonance imaging at 7 Tesla demonstrates the complexity of ultra-high-field breast magnetic resonance imaging and countenances the implementation of further advanced bilateral coil concepts to circumvent current limitations from the coil and ultra-high-field magnetic strength.
本研究旨在评估 7T 场强下动态对比增强超高频乳腺成像的可行性。
共纳入 15 例受试者，包括 5 例经组织学证实的乳腺癌患者，使用单侧线性极化单环线圈在 7T 全身磁共振成像系统上进行检查。受试者采用俯卧位，活检支撑系统置于线圈正下方，感兴趣区置于线圈中心。检查方案包括：1）T2 加权快速自旋回波序列；2）6 个动态 T1 加权扰相梯度回波序列；3）减影成像。
高空间分辨率、短采集时间的 7T 场强下可获得增强 T1 加权成像，为小解剖和病理结构提供了良好的图像准确性和明确的边界。在适当的采集时间内，可获得高空间分辨率的 T2 加权成像。由于线圈的限制，4 例高场磁共振检查的诊断价值降低。
这是首次在 7T 场强下进行的动态对比增强乳腺磁共振成像的科学研究，证明了超高场乳腺磁共振成像的复杂性，并考虑实施进一步的先进双侧线圈概念来规避当前线圈和超高场强带来的局限性。
