Salkowski C A, Balish E
University of Wisconsin Medical School, Department of Surgery, Madison.
Can J Microbiol. 1991 Feb;37(2):128-35. doi: 10.1139/m91-019.
The influence of the beige (bg/bg) mutation on susceptibility to cryptococcosis was assessed by mortality, quantitative culturing, and histopathology of infected organs from bg/bg and bg/+ mice. Immunodeficient bg/bg mice were more susceptible to systemic cryptococcosis than immunocompetent bg/+ mice. Differences in susceptibility of bg/bg and bg/+ mice corresponded with temporal differences in histopathology. In contrast to bg/+ mice, inflammatory responses in infected tissues from bg/bg mice contained less cellular infiltrate, proportionally more polymorphonuclear neutrophils than monocytes and macrophages, and delays in the switch from acute to chronic inflammation. Enhanced growth of Cryptococcus neoformans in the internal organs of bg/bg mice was coincident with delayed inflammatory responses. These quantitative culture and histopathology studies suggest that the defects associated with monocytes and macrophages and polymorphonuclear neutrophils resulted in altered in vivo inflammatory responses and contributed to the enhanced susceptibility of beige mice to C. neoformans.
通过对bg/bg和bg/+小鼠感染器官的死亡率、定量培养和组织病理学分析，评估米色（bg/bg）突变对隐球菌病易感性的影响。免疫缺陷的bg/bg小鼠比具有免疫能力的bg/+小鼠对系统性隐球菌病更易感。bg/bg和bg/+小鼠易感性的差异与组织病理学的时间差异相对应。与bg/+小鼠不同，bg/bg小鼠感染组织中的炎症反应细胞浸润较少，多形核中性粒细胞与单核细胞和巨噬细胞的比例更高，并且从急性炎症向慢性炎症转变存在延迟。新型隐球菌在bg/bg小鼠内脏器官中的生长增强与炎症反应延迟同时出现。这些定量培养和组织病理学研究表明，与单核细胞、巨噬细胞和多形核中性粒细胞相关的缺陷导致体内炎症反应改变，并导致米色小鼠对新型隐球菌的易感性增强。
