不同的巨噬细胞亚群调节中枢神经系统中的病毒脑炎但不调节病毒清除。
Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.
机构信息
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA.
出版信息
J Neuroimmunol. 2010 Sep 14;226(1-2):81-92. doi: 10.1016/j.jneuroim.2010.05.034.
Abstract
Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS.
摘要
鼻腔内应用水疱性口炎病毒（VSV）会引发以髓系细胞和 T 细胞浸润为特征的急性脑炎。因此，本研究检测了不同吞噬细胞群体在 VSV 脑炎中的作用。外周巨噬细胞的清除并不影响 VSV 脑炎或病毒从大脑中的清除，而脾边缘区树突状细胞的耗竭则会损害这种反应，并增加发病率/死亡率。选择性耗尽脑小血管周围的巨噬细胞也会抑制这种反应，而不改变病毒在中枢神经系统中的清除。因此，两种解剖上不同的吞噬细胞群体以非冗余的方式调节 VSV 脑炎，尽管这两种群体对中枢神经系统中的病毒清除都不是必需的。
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