基因表达有助于在中枢神经系统感染水疱性口炎病毒后募集循环细胞。
Gene expression contributing to recruitment of circulating cells in response to vesicular stomatitis virus infection of the CNS.
作者信息
Ireland Derek D C, Reiss Carol Shoshkes
机构信息
Department of Biology, New York University, New York, New York 10003-6688, USA.
出版信息
Viral Immunol. 2006 Summer;19(3):536-45. doi: 10.1089/vim.2006.19.536.
Abstract
During acute Vesicular Stomatitis Virus (VSV) infection of the mouse central nervous system, neutrophils, natural killer (NK) cells, macrophages, and CD4+ and CD8+ T cells are recruited from the circulation in response to chemokines and cytokines. This study elucidated the production of these factors and infiltration of these peripheral cells. Chemokines that were observed included CCL1, CXCL10 (IP-10), CCL5 (RANTES), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CXCL1 (MIP-2), CCL2 (MCP-1), and CCL11 (eotaxin). Cytokines produced in response to the infection include IL-1 and interferon-gamma, but not type I interferons. Neutrophils are the first recruited cell type, appearing as early as 24 h after intranasal application of the virus. NK cells follow, but T cells are not detected until 6 days postinfection.
摘要
在小鼠中枢神经系统急性水泡性口炎病毒（VSV）感染期间，嗜中性粒细胞、自然杀伤（NK）细胞、巨噬细胞以及CD4+和CD8+ T细胞会响应趋化因子和细胞因子从循环系统中被募集而来。本研究阐明了这些因子的产生以及这些外周细胞的浸润情况。观察到的趋化因子包括CCL1、CXCL10（IP - 10）、CCL5（RANTES）、CCL3（MIP - 1α）、CCL4（MIP - 1β）、CXCL1（MIP - 2）、CCL2（MCP - 1）和CCL11（嗜酸性粒细胞趋化因子）。感染后产生的细胞因子包括IL - 1和干扰素 - γ，但不包括I型干扰素。嗜中性粒细胞是最早被募集的细胞类型，在鼻内接种病毒后24小时就开始出现。NK细胞随后出现，但直到感染后6天才能检测到T细胞。
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