Department of Internal Medicine, Creighton University Medical Center, Omaha, NE, United States.
Crit Rev Oncol Hematol. 2011 Jun;78(3):227-42. doi: 10.1016/j.critrevonc.2010.06.001. Epub 2010 Jul 5.
Cancer is a disease of the elderly with the majority of new diagnoses and deaths from cancer occurring in persons greater than 65 years of age. A major goal of cancer therapy, in the elderly is the preservation of functional independence and quality of life. The advent of targeted therapies has raised the hope that older patients with cancer could be treated as effectively as younger patients and without added toxicities. However, caution must be exercised while addressing the use of these therapies in the elderly population and only after taking into consideration the risks, benefits and prognosis of patients on an individual basis. This article reviews the current literature on the efficacy, cost-effectiveness and toxicity of the currently approved targeted agents in the elderly population.
癌症是一种老年病，大多数新诊断的癌症病例和癌症死亡病例发生在 65 岁以上的人群中。癌症治疗的一个主要目标是在老年人中保持功能独立性和生活质量。靶向治疗的出现带来了希望，即老年癌症患者可以像年轻患者一样有效地接受治疗，而且不会增加毒性。然而，在考虑在老年人群中使用这些疗法时必须谨慎，并且只能在考虑到患者的风险、获益和预后的基础上进行。本文综述了目前在老年人群中批准的靶向药物的疗效、成本效益和毒性的相关文献。
