Laboratoire de Neurosciences, Université de Franche-Comté, Place Leclerc, 25,000 Besançon, France.
Behav Brain Res. 2010 Dec 20;215(1):58-62. doi: 10.1016/j.bbr.2010.06.024. Epub 2010 Jun 25.
Environmental stimuli and adverse experiences in early life may result in behavioral and physiological changes in adulthood. In several animal species, the odors cues are crucial in the setting of adaptive behaviors, especially towards predators. However, little is known about the effects of postnatal exposure to predator odor on the later physiological and behavioral responses to this natural stressor. Thus, the aim of this study was to investigate the effects of a postnatal exposure to synthetic predator odor (TMT) in mice pups on later adult fear-related behaviors and corticosterone levels in response to this specific stimulus. Pups postnatally exposed to only water showed later in adult life behavioral responses when exposed to TMT that were statistically different from mice that were exposed as neonates to TMT. In addition, mice exposed as neonates to TMT showed a decrease of fear-related behaviors while no differences occurred in the corticosterone levels between both groups.
环境刺激和早期生活中的不良经历可能导致成年后的行为和生理变化。在几种动物物种中，气味线索对于适应行为的形成至关重要，尤其是对于捕食者。然而，对于出生后暴露于捕食者气味对随后对这种自然应激源的生理和行为反应的影响知之甚少。因此，本研究旨在调查新生期暴露于合成捕食者气味（TMT）对成年后与恐惧相关的行为和皮质酮水平的影响。仅在水中暴露的幼鼠在成年后暴露于 TMT 时表现出的行为反应在统计学上与新生期暴露于 TMT 的幼鼠不同。此外，新生期暴露于 TMT 的幼鼠表现出与恐惧相关的行为减少，而两组之间的皮质酮水平没有差异。
