Centre des Sciences du Goût et de l'Alimentation, Université de Franche-Comté, Place Leclerc 25000 Besançon, France.
Behav Brain Res. 2013 Feb 1;238:227-31. doi: 10.1016/j.bbr.2012.10.014. Epub 2012 Oct 23.
Few comparisons were made between cat odor and synthetic fox odor (TMT) to study fear and anxiety in rodents. TMT is frequently used are at high concentration while the stimulus should be as possible closer to natural conditions. The aim of this work was to compare behavioral responses of mice exposed to cat odor and low doses of TMT (i.e. 10 μl of a solution containing 1%, 0.1% or 0.01% TMT). Behavioral parameters were recorded in elevated plus-maze and in open field. Results showed that 1% TMT and 0.1% TMT induced similar responses to cat odor, contrary to water and 0.01% TMT which failed to elicit fear or anxiety-related behaviors. Additionally, behavioral changes were more marked in EPM - e.g. time spent in open arms - than in open field - e.g. freezing. These findings are discussed in terms of a possible continuum of mild anxiety-like behaviors to strong fear-like behaviors linked to predator odor intensity.
很少有研究将猫臭和合成狐狸臭（TMT）进行比较，以研究啮齿动物的恐惧和焦虑。TMT 经常在高浓度下使用，而刺激应该尽可能接近自然条件。这项工作的目的是比较暴露于猫臭和低剂量 TMT（即含有 1%、0.1%或 0.01%TMT 的溶液 10μl）的小鼠的行为反应。行为参数在高架十字迷宫和开阔场中记录。结果表明，1%TMT 和 0.1%TMT 引起的反应与猫臭相似，而与水和 0.01%TMT 相反，水和 0.01%TMT 未能引起恐惧或焦虑相关行为。此外，行为变化在 EPM 中更为明显 - 例如在开放臂上花费的时间 - 而在开阔场中 - 例如冻结。这些发现根据与捕食者气味强度相关的轻度类似焦虑行为到强烈类似恐惧行为的连续体进行了讨论。
