Ooshima T, Hashida T, Fuchihata H, Fujiwara T, Yoshida T, Izumitani A, Sobue S, Hamada S
Department of Pedodontics, Osaka University Faculty of Dentistry, Yamadaoka, Japan.
Caries Res. 1991;25(2):138-42. doi: 10.1159/000261356.
The effects of hyposalivation on the induction of dental caries and on the oral microflora were examined in SPF Sprague-Dawley rats with or without inoculation of oral streptococci. Significant dental caries was induced in hyposalivated rats, irrespective of the infection with oral streptococci including Streptococcus mutans. In addition, bacteriological analyses demonstrated that the total number of lactobacilli increased significantly at the expense of the inoculated streptococci. These findings suggest that opportunistic infections may be induced in the oral cavity of hyposalivated rats and some acidogenic microorganisms including lactobacilli may promote the induction of dental caries.
在有无接种口腔链球菌的无特定病原体（SPF）斯普拉格-道利大鼠中，研究了唾液分泌减少对龋齿诱导及口腔微生物群的影响。无论是否感染包括变形链球菌在内的口腔链球菌，唾液分泌减少的大鼠都会出现明显的龋齿。此外，细菌学分析表明，乳酸杆菌总数显著增加，而接种的链球菌数量减少。这些发现表明，唾液分泌减少的大鼠口腔可能会发生机会性感染，包括乳酸杆菌在内的一些产酸微生物可能会促进龋齿的发生。
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