实验性唾液分泌减少对感染变形链球菌的大鼠龋齿诱导的影响。

Effect of experimental hyposalivation on the induction of dental caries in rats infected with Streptococcus mutans.

作者信息

Ooshima T, Hashida T, Fuchihata H, Fujiwara T, Yoshida T, Izumitani A

机构信息

Department of Pedodontics, Osaka University, Faculty of Dentistry, Japan.

出版信息

Caries Res. 1990;24(6):446-51. doi: 10.1159/000261307.

DOI:10.1159/000261307

PMID:2149676

Abstract

The effects of hyposalivation on the induction of dental caries were examined in specific pathogen-free Sprague-Dawley rats infected with Streptococcus mutans MT8148R and fed the caries-inducing diet 2000. Hyposalivation was induced by either irradiation or surgical removal of salivary glands in 30-day-old rats. After either procedure, severe dental caries was induced in the rats when examined at 84 days of age, and a statistically significant correlation was found between caries scores and flow rates of saliva. However, the recovery of strain MT8148R from hyposalivated rats was not always high, and it is possible that microorganisms other than the inoculated S. mutans strain MT8148R may have played a role in promoting dental caries.

摘要

在感染变形链球菌MT8148R并喂食致龋饮食2000的无特定病原体斯普拉格-道利大鼠中，研究了唾液分泌减少对龋齿诱导的影响。通过对30日龄大鼠进行唾液腺照射或手术切除来诱导唾液分泌减少。在这两种操作后的任何一种之后，在84日龄检查时，大鼠都发生了严重龋齿，并且在龋齿评分与唾液流速之间发现了具有统计学意义的相关性。然而，从唾液分泌减少的大鼠中回收菌株MT8148R的效率并不总是很高，并且有可能除接种的变形链球菌菌株MT8148R之外的其他微生物在促进龋齿方面发挥了作用。