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Focus on molecules: Akt (PKB).聚焦分子:Akt(蛋白激酶B)。
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2
Focus on molecules: phosphatidylinositol-4,5-bisphosphate (PIP2).聚焦分子:磷脂酰肌醇-4,5-二磷酸(PIP2)。
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The phosphoinositide 3-kinase pathway.磷酸肌醇3激酶通路
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Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.在致死性磷脂酰肌醇-3,4,5-三磷酸(PIP3)水平下存活:通过Akt/蛋白激酶B(PKB)中的pleckstrin同源(PH)结构域突变恢复缺乏磷酸酶及张力蛋白同源物(PTEN)的果蝇的生存能力。
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Phosphoinositide 3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death.β-半乳糖苷结合蛋白细胞因子对磷酸肌醇3-激酶的靶向作用可使akt基因表达失活,并导致侵袭性乳腺癌细胞凋亡。
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Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.血清撤除诱导分化中的3T3-L6成肌细胞中磷酸肌醇3激酶脂质蓄积:Ship2和PTEN的不同作用
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Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.SHIP-1在T淋巴细胞中参与磷脂酰肌醇3,4,5-三磷酸代谢并可调节新型磷酸肌醇3-激酶效应器的证据。
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Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis.磷酸肌醇依赖的蛋白激酶(PDK)活性调节磷酸肌醇 3,4,5-三磷酸依赖性和非依赖性蛋白激酶 B 的激活和趋化作用。
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Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.磷脂酰肌醇 4,5-二磷酸特异性 AKT1 致癌。
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Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review).羧基末端调制蛋白 1 概述及其在各种代谢调节中的重要性(综述)。
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Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells-Deciphering Novel Potential Targets for a Cell Sensitization.基质诱导的乳腺癌细胞化学抗性机制——解读细胞致敏的新型潜在靶点
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Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway.整合素激活通过诱导Wnt信号通路导致MV3黑色素瘤细胞对顺铂的敏感性降低。
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Role of AKT signaling in DNA repair and clinical response to cancer therapy.AKT信号通路在DNA修复及癌症治疗临床反应中的作用
Neuro Oncol. 2014 Oct;16(10):1313-23. doi: 10.1093/neuonc/nou058. Epub 2014 May 7.
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Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.乳酸通过结合受体酪氨酸激酶 Axl、Tie2 和血管内皮生长因子受体 2 来激活磷酸肌醇 3-激酶/蛋白激酶 B(Akt)并促进血管生成。
J Biol Chem. 2013 Jul 19;288(29):21161-21172. doi: 10.1074/jbc.M113.474619. Epub 2013 Jun 10.

本文引用的文献

1
AKT/PKB signaling: navigating downstream.AKT/蛋白激酶B信号传导:下游通路解析
Cell. 2007 Jun 29;129(7):1261-74. doi: 10.1016/j.cell.2007.06.009.
2
The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.支架衔接蛋白Gab1介导血管内皮生长因子信号传导,是内皮细胞迁移和毛细血管形成所必需的。
J Biol Chem. 2007 Mar 16;282(11):7758-69. doi: 10.1074/jbc.M611327200. Epub 2006 Dec 17.
3
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.rictor-mTOR复合物对Akt/PKB的磷酸化及调控
Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148.
4
Physiological functions of protein kinase B/Akt.
Biochem Soc Trans. 2004 Apr;32(Pt 2):350-4. doi: 10.1042/bst0320350.

Focus on molecules: Akt (PKB).

作者信息

Ruan Guo-Xiang, Kazlauskas Andrius

机构信息

The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA.

出版信息

Exp Eye Res. 2011 Nov;93(5):570-1. doi: 10.1016/j.exer.2010.06.016. Epub 2010 Jun 23.

DOI:10.1016/j.exer.2010.06.016
PMID:20599963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3744866/
Abstract
摘要