口服活重组减毒鼠伤寒沙门氏菌递送鼠疫耶尔森氏菌分泌形式 PsaA 疫苗对小鼠体液免疫应答的评估。
Evaluation of the humoral immune response in mice orally vaccinated with live recombinant attenuated Salmonella enterica delivering a secreted form of Yersinia pestis PsaA.
机构信息
Center for Infectious Disease and Vaccinology at the Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ 85287-5401, USA.
出版信息
Vaccine. 2010 Aug 16;28(36):5810-6. doi: 10.1016/j.vaccine.2010.06.070. Epub 2010 Jul 13.
Abstract
Yersinia pestis PsaA is an adhesin that is synthesized inside macrophages. Here, we evaluated the immune profile of codon-optimized Y. pestis PsaA synthesized in a live recombinant attenuated Salmonella vaccine (RASV) strain chi9558. Oral immunization of BALB/c mice with chi9558(pYA3705) delivering a secreted form of PsaA, elicited a systemic PsaA-specific immunoglobulin G (IgG) response but offered limited protection against lethal challenge with the intranasally introduced Y. pestis CO92 strain. Our results suggest that appropriate fine-tuning of Y. pestis PsaA delivery by RASV could improve its protective role in curtailing plague colonization and infection.
摘要
鼠疫耶尔森氏菌 PsaA 是一种黏附素，在巨噬细胞内合成。在这里，我们评估了在活重组减毒沙门氏菌疫苗（RASV）菌株 chi9558 中合成的密码子优化鼠疫耶尔森氏菌 PsaA 的免疫谱。用 chi9558(pYA3705)口服免疫 BALB/c 小鼠，该菌可分泌 PsaA，引发全身性 PsaA 特异性免疫球蛋白 G（IgG）反应，但对用鼻内引入的鼠疫耶尔森氏菌 CO92 菌株进行的致死性攻击提供的保护作用有限。我们的结果表明，通过 RASV 适当调整鼠疫耶尔森氏菌 PsaA 的递送，可以提高其在遏制鼠疫定植和感染方面的保护作用。
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