Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.
Int J Biochem Cell Biol. 2010 Oct;42(10):1614-7. doi: 10.1016/j.biocel.2010.06.019. Epub 2010 Jun 30.
Fascin is a 55 kDa actin-bundling protein and is an important regulatory element in the maintenance and stability of parallel bundles of filamentous actin in a variety of cellular contexts. Regulation of fascin function is under the control of a number of different signalling pathways that act in concert to spatially regulate the actin-binding properties of this protein. The ability of fascin to bind and bundle actin plays a central role in the regulation of cell adhesion, migration and invasion. Fascin has received considerable attention recently as an emerging key prognostic marker of metastatic disease. Studies are now underway to better understand the precise regulation of this protein in the context of tumour progression and to investigate fascin as a potential therapeutic target for a number of forms of cancer.
Fascin 是一种 55kDa 的肌动蛋白成束蛋白，是在多种细胞环境中维持和稳定丝状肌动蛋白平行束的重要调节元件。 Fascin 功能的调节受到许多不同信号通路的控制，这些信号通路协同作用，空间调节该蛋白的肌动蛋白结合特性。 Fascin 结合和束状肌动蛋白的能力在细胞黏附、迁移和侵袭的调节中起着核心作用。 Fascin 最近作为转移性疾病的一个新兴关键预后标志物受到了广泛关注。目前正在进行研究，以更好地了解该蛋白在肿瘤进展背景下的精确调节，并研究 Fascin 作为多种癌症的潜在治疗靶点的可能性。
