Department of Clinical Sciences, Hospital Luigi Sacco, Department of Medicine and Medical Specialties, University of Milan, Milan, Italy.
Reprod Sci. 2010 Sep;17(9):844-8. doi: 10.1177/1933719110371516. Epub 2010 Jul 2.
Intrauterine growth restriction (IUGR) depends on the placental capacity to transfer oxygen and nutrients from the maternal to the fetal circulation. Placental insufficiency may be caused by impairment of the maternal or fetal circulation by a thrombotic event, possibly associated with thrombophilic disorders. The goals of our study were to define the role of maternal/fetal gain-of-function factor V Leiden and prothrombin G20210A mutations in the development of IUGR and to evaluate whether maternal pregnancy-induced hypertensive diseases would modify any such association. This is a case-control study: controls were 259 normal pregnancies, cases were 77 IUGR, 28 with and 49 without preeclampsia (PE) or pregnancy-induced hypertension (PIH). An association was found between IUGR and fetal thrombophilia (OR 2.09 CI 95% 1-4.5). The association was stronger in IUGR without PE and PIH (OR 2.9 CI 95% 1.3-6.6). This suggests a role for the fetal genotype in the development of IUGR.
胎儿生长受限（IUGR）取决于胎盘将氧气和营养物质从母体转运至胎儿循环的能力。胎盘功能不全可能由母体或胎儿循环的血栓事件引起，可能与血栓形成倾向疾病有关。我们的研究目的是确定母体/胎儿功能获得性因子 V 莱顿和凝血酶原 G20210A 突变在 IUGR 发展中的作用，并评估母体妊娠高血压疾病是否会改变任何这种关联。这是一项病例对照研究：对照组为 259 例正常妊娠，病例组为 77 例 IUGR，28 例伴或不伴子痫前期（PE）或妊娠高血压（PIH）。IUGR 与胎儿血栓形成倾向之间存在关联（OR 2.09，95%CI 1-4.5）。在无 PE 和 PIH 的 IUGR 中，这种关联更强（OR 2.9，95%CI 1.3-6.6）。这表明胎儿基因型在 IUGR 的发展中起作用。
