遗传、表观遗传和基因-饮食相互作用导致 LG/JxSM/J 鼠模型血清脂质的变化。
Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model.
机构信息
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
J Lipid Res. 2010 Oct;51(10):2976-84. doi: 10.1194/jlr.M006957. Epub 2010 Jul 2.
Abstract
Variation in serum cholesterol, free-fatty acids, and triglycerides is associated with cardiovascular disease (CVD) risk factors. There is great interest in characterizing the underlying genetic architecture of these risk factors, because they vary greatly within and among human populations and between the sexes. We present results of a genome-wide scan for quantitative trait loci (QTL) affecting serum cholesterol, free-fatty acids, and triglycerides in an F(16) advanced intercross line of LG/J and SM/J (Wustl:LG,SM-G16). Half of the population was fed a high-fat diet and half was fed a relatively low-fat diet. Context-dependent genetic (additive and dominance) and epigenetic (imprinting) effects were characterized by partitioning animals into sex, diet, and sex-by-diet cohorts. Here we examine genetic, environmental, and genetic-by-environmental interactions of QTL overlapping previously identified loci associated with CVD risk factors, and we add to the serum lipid QTL landscape by identifying new loci.
摘要
血清胆固醇、游离脂肪酸和甘油三酯的变化与心血管疾病 (CVD) 风险因素有关。人们对这些风险因素的潜在遗传结构特征非常感兴趣，因为它们在人类群体内部和群体之间以及性别之间存在很大差异。我们展示了一项针对影响 LG/J 和 SM/J（Wustl:LG，SM-G16）F(16) 近交系系血清胆固醇、游离脂肪酸和甘油三酯的数量性状基因座 (QTL) 的全基因组扫描结果。一半的人群喂食高脂肪饮食，另一半喂食相对低脂肪饮食。通过将动物分为性别、饮食和性别-饮食队列，对遗传（加性和显性）和表观遗传（印迹）效应进行了特征分析。在这里，我们检查了与 CVD 风险因素相关的先前确定的 QTL 重叠的 QTL 的遗传、环境和遗传-环境相互作用，并通过鉴定新的基因座来增加血清脂质 QTL 景观。
相似文献
1
Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model.遗传、表观遗传和基因-饮食相互作用导致 LG/JxSM/J 鼠模型血清脂质的变化。
J Lipid Res. 2010 Oct;51(10):2976-84. doi: 10.1194/jlr.M006957. Epub 2010 Jul 2.
2
Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations.多效性位点的遗传效应具有情境依赖性，会对群体中遗传变异的维持产生影响。
PLoS Genet. 2011 Sep;7(9):e1002256. doi: 10.1371/journal.pgen.1002256. Epub 2011 Sep 8.
3
The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model.对 LG/J × SM/J 鼠模型进行全基因组扫描揭示了环境因素对糖尿病相关特征遗传结构的重要性。
Mamm Genome. 2011 Apr;22(3-4):197-208. doi: 10.1007/s00335-010-9313-3. Epub 2011 Jan 6.
4
Diet-dependent genetic and genomic imprinting effects on obesity in mice.饮食依赖的遗传和基因组印迹效应对小鼠肥胖的影响。
Obesity (Silver Spring). 2011 Jan;19(1):160-70. doi: 10.1038/oby.2010.141. Epub 2010 Jun 10.
5
Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross.遗传因素和饮食影响 F34LG、SM 高级杂交系的长骨长度。
Mamm Genome. 2011 Apr;22(3-4):178-96. doi: 10.1007/s00335-010-9311-5. Epub 2010 Dec 19.
6
Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity.在LG/J×SM/J肥胖小鼠模型中对13号染色体上基因与饮食相互作用进行精细定位。
Diabetes. 2005 Jun;54(6):1863-72. doi: 10.2337/diabetes.54.6.1863.
7
Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population.性别和饮食对SM/J与NZB/BlNJ杂交群体中高密度脂蛋白胆固醇水平数量性状位点的影响。
J Lipid Res. 2004 May;45(5):881-8. doi: 10.1194/jlr.M300460-JLR200. Epub 2004 Mar 1.
8
Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.利用LG/J和SM/J近交系小鼠品系的全基因组序列对数量性状基因和核苷酸进行优先级排序。
BMC Genomics. 2015 May 28;16(1):415. doi: 10.1186/s12864-015-1592-3.
9
Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.在NZB/B1NJxRF/J杂交组合以及涉及NZB/B1NJ、RF/J、MRL/MpJ和SJL/J小鼠品系的联合杂交中定位调控脂质水平的基因座。
J Lipid Res. 2007 Aug;48(8):1724-34. doi: 10.1194/jlr.M700015-JLR200. Epub 2007 May 13.
10
Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.在LG/J与SM/J高级杂交系中对影响小鼠外耳组织再生的数量性状基因座进行精细定位。
Heredity (Edinb). 2014 May;112(5):508-18. doi: 10.1038/hdy.2013.133. Epub 2014 Feb 26.
引用本文的文献
1
Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation.通过表观遗传和转录调控，精确药理学逆转小鼠特定饮食引起的代谢综合征的研究
PLoS Genet. 2023 Oct 23;19(10):e1010997. doi: 10.1371/journal.pgen.1010997. eCollection 2023 Oct.
2
Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression.遗传、表观遗传和环境机制控制着等位基因特异性基因表达。
Genome Res. 2022 Jun;32(6):1042-1057. doi: 10.1101/gr.276193.121. Epub 2022 May 2.
3
Parent-of-origin effects propagate through networks to shape metabolic traits.亲本来源效应通过网络传播，从而塑造代谢特征。
Elife. 2022 Mar 31;11:e72989. doi: 10.7554/eLife.72989.
4
Spontaneous restoration of functional β-cell mass in obese SM/J mice.肥胖 SM/J 小鼠功能性β细胞质量的自发恢复。
Physiol Rep. 2020 Oct;8(20):e14573. doi: 10.14814/phy2.14573.
5
Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice.棕色脂肪扩张和肥胖 SM/J 小鼠血糖功能障碍的缓解。
Cell Rep. 2020 Oct 6;33(1):108237. doi: 10.1016/j.celrep.2020.108237.
6
Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes.遗传背景和饮食会影响与代谢表型相关的棕色脂肪基因共表达网络。
Physiol Genomics. 2020 Jun 1;52(6):223-233. doi: 10.1152/physiolgenomics.00003.2020. Epub 2020 Apr 27.
7
Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits.使用异质群体对复杂遗传性状进行精细定位。
Methods Mol Biol. 2019;2018:233-247. doi: 10.1007/978-1-4939-9581-3_11.
8
Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans.生理学和遗传学证据表明，在小鼠和人类中，血红素结合蛋白与甘油三酯存在关联。
Int J Obes (Lond). 2017 Apr;41(4):631-638. doi: 10.1038/ijo.2017.19. Epub 2017 Jan 25.
9
Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics.西班牙裔2型糖尿病和血脂性状的全基因组研究。
Curr Diab Rep. 2016 May;16(5):41. doi: 10.1007/s11892-016-0737-3.
10
Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.利用LG/J和SM/J近交系小鼠品系的全基因组序列对数量性状基因和核苷酸进行优先级排序。
BMC Genomics. 2015 May 28;16(1):415. doi: 10.1186/s12864-015-1592-3.
本文引用的文献
1
Diet-dependent genetic and genomic imprinting effects on obesity in mice.饮食依赖的遗传和基因组印迹效应对小鼠肥胖的影响。
Obesity (Silver Spring). 2011 Jan;19(1):160-70. doi: 10.1038/oby.2010.141. Epub 2010 Jun 10.
2
Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.钙蛋白酶-10 是肥胖相关数量性状位点 Adip1 的一个组成部分。
J Lipid Res. 2010 May;51(5):907-13. doi: 10.1194/jlr.M900128.
3
Metabolic syndrome components in murine models.小鼠模型中的代谢综合征组成部分。
Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):25-40. doi: 10.2174/187153010790827948.
4
Detection of imprinting and heterogeneous maternal effects on high blood pressure using Framingham Heart Study data.利用弗雷明汉心脏研究数据检测印记和异质性母体效应与高血压的关系。
BMC Proc. 2009 Dec 15;3 Suppl 7(Suppl 7):S125. doi: 10.1186/1753-6561-3-s7-s125.
5
The genetics of cardiovascular disease: new insights from emerging approaches.心血管疾病的遗传学：新兴方法的新见解。
J Pathol. 2010 Jan;220(2):186-97. doi: 10.1002/path.2641.
6
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.血浆高密度脂蛋白胆固醇与冠状动脉粥样硬化严重程度的候选基因分析
BMC Med Genet. 2009 Oct 30;10:111. doi: 10.1186/1471-2350-10-111.
7
The role of GNAS and other imprinted genes in the development of obesity.GNAS 基因和其他印迹基因在肥胖发生发展中的作用。
Int J Obes (Lond). 2010 Jan;34(1):6-17. doi: 10.1038/ijo.2009.222. Epub 2009 Oct 20.
8
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.结合小鼠和人类遗传学方法鉴定UBP1基因座为关键血压决定因素。
PLoS Genet. 2009 Aug;5(8):e1000591. doi: 10.1371/journal.pgen.1000591. Epub 2009 Aug 7.
9
The genetics of quantitative traits: challenges and prospects.数量性状的遗传学：挑战与前景
Nat Rev Genet. 2009 Aug;10(8):565-77. doi: 10.1038/nrg2612.
10
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.全基因组关联位点对人类疾病和性状的潜在病因学及功能影响。
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7. doi: 10.1073/pnas.0903103106. Epub 2009 May 27.
Zotero 插件