伊朗伊斯法罕地区学生甲状腺肿的高患病率；锌缺乏并无作用。

High prevalence of goiter in schoolchildren in Isfahan; zinc deficiency does not play a role.

机构信息

Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Endokrynol Pol. 2010 May-Jun;61(3):287-90.

PMID:20602304

Abstract

INTRODUCTION

There are controversial data about the role of zinc deficiency in the aetiology of endemic goiter. The aim of the present study was to determine the association between zinc status and goiter in schoolchildren of Isfahan.

MATERIAL AND METHODS

This study was performed in 2005. Two thousand three hundred and thirty-one schoolchildren were enrolled, and thyroid size was determined by inspection and palpation. Urinary iodine concentration (UIC) and serum zinc level were measured in a group of those children.

RESULTS

The prevalence of goiter was 32.9%. The median UIC was 195.5 microg/L. Serum zinc was measured in 94 goitrous and 326 nongoitrous children. The mean + or - standard deviation of serum zinc in goitrous and non-goitrous children was 100.81 + or - 22.33 and 96.00 + or - 25.79 microg/dL, respectively (P = 0.08). The prevalence of zinc deficiency (serum zinc < or = 65 microg/dL) in goitrous and non-goitrous children did not differ significantly (6.4 % v. 8.0%, P = 0.61).

CONCLUSIONS

The prevalence of goiter is still high in Isfahan schoolchildren. It seems that zinc status is not involved in the high prevalence of goiter in this region. The role of other possible goitrogens should be investigated in Isfahan.

摘要

简介

锌缺乏在地方性甲状腺肿的病因学中作用存在争议。本研究的目的是确定锌状态与伊斯法罕地区学童甲状腺肿之间的关系。

材料与方法

这项研究于 2005 年进行。共有 2331 名学生被纳入研究，通过触诊和视诊确定甲状腺大小。对其中一组儿童测量尿碘浓度（UIC）和血清锌水平。

结果

甲状腺肿的患病率为 32.9%。UIC 的中位数为 195.5μg/L。对 94 名甲状腺肿和 326 名非甲状腺肿儿童进行了血清锌测量。甲状腺肿和非甲状腺肿儿童的血清锌均值±标准差分别为 100.81±22.33 和 96.00±25.79μg/dL（P=0.08）。甲状腺肿和非甲状腺肿儿童的锌缺乏患病率（血清锌≤65μg/dL）差异无统计学意义（6.4%比 8.0%，P=0.61）。