Keshteli Ammar H, Hashemipour Mahin, Siavash Mansour, Amini Masoud
Medical Students Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Biol Trace Elem Res. 2009 Summer;129(1-3):70-7. doi: 10.1007/s12011-008-8296-3. Epub 2008 Dec 18.
The prevalence of goiter still remains high in some areas of Iran in spite of iodine supplementation. In the present study, we investigated the role of selenium (Se) deficiency in the etiology of goiter in Isfahan. Two thousand three hundred thirty-one schoolchildren were selected by multistage random sampling. Thyroid size was estimated in each child by inspection and palpation. Urinary iodine concentration (UIC) and plasma Se were measured. Overall, 32.9% of the 2,331 children had goiter. The median UIC was 19.55 microg/dl. Plasma Se was measured in 96 goitrous and 72 nongoitrous children. The mean +/- SD of plasma Se in goitrous and nongoitrous children was 66.86 +/- 21.82 and 76.67 +/- 23.33 microg/l, respectively (P = 0.006). Goitrous girls had lower plasma Se level than nongoitrous girls (65.62 +/- 21.64 vs. 76.51 +/- 22.61 microg/dl, P = 0.02). Goitrous boys had lower plasma Se level than nongoitrous boys (68.45 +/- 22.21 vs. 76.91 +/- 24.76 microg/l, P = 0.14). The prevalence of Se deficiency was significantly higher in goitrous boys and girls than nongoitrous children. Se deficiency is among the contributors of goiter in Isfahan goitrous schoolchildren. However, the role of other micronutrient deficiencies or goitrogens should be investigated in this region.
尽管伊朗已进行碘补充，但在该国一些地区，甲状腺肿的患病率仍然很高。在本研究中，我们调查了伊朗伊斯法罕地区硒（Se）缺乏在甲状腺肿病因中的作用。通过多阶段随机抽样选取了2331名学童。通过视诊和触诊对每个儿童的甲状腺大小进行评估。测量尿碘浓度（UIC）和血浆硒。总体而言，2331名儿童中有32.9%患有甲状腺肿。UIC中位数为19.55微克/分升。对96名甲状腺肿儿童和72名非甲状腺肿儿童测量了血浆硒。甲状腺肿儿童和非甲状腺肿儿童的血浆硒平均±标准差分别为66.86±21.82和76.67±23.33微克/升（P = 0.006）。患甲状腺肿的女孩血浆硒水平低于未患甲状腺肿的女孩（65.62±21.64对76.51±22.61微克/分升，P = 0.02）。患甲状腺肿的男孩血浆硒水平低于未患甲状腺肿的男孩（68.45±22.21对76.91±24.76微克/升，P = 0.14）。患甲状腺肿的男孩和女孩中硒缺乏的患病率显著高于未患甲状腺肿的儿童。硒缺乏是伊斯法罕患甲状腺肿学童甲状腺肿的促成因素之一。然而，该地区其他微量营养素缺乏或致甲状腺肿物质的作用也应进行调查。
