Brown D M, Charonis A S, Furcht L T, Klein D J, Mauer S M, Steffes M W, Tsilibary P E
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
Diabetes Care. 1991 Feb;14(2):157-9. doi: 10.2337/diacare.14.2.157.
The glomerular filtration barrier consists of complex matrix constituents interposed between the glomerular endothelial and epithelial cells, which constitute the lining of the glomerular capillaries. The matrix components include collagen and noncollagenous molecules such as laminin and proteoglycans. This review describes herein the metabolic consequences of diabetes mellitus to which increased permeability of the filtration barrier may be attributed by altering matrix molecules.
肾小球滤过屏障由介于肾小球内皮细胞和上皮细胞之间的复杂基质成分组成，这些细胞构成了肾小球毛细血管的内衬。基质成分包括胶原蛋白和非胶原蛋白分子，如层粘连蛋白和蛋白聚糖。本综述在此描述了糖尿病的代谢后果，滤过屏障通透性增加可能归因于基质分子的改变。
