Azlin M I Nor, Bang H Kee, An L Joe, Mohamad S N, Mansor N A, Yee B See, Zulkifli N H, Tamil A Mohd
Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
J Obstet Gynaecol. 2010;30(5):456-9. doi: 10.3109/01443615.2010.489162.
This prospective observational study was to evaluate the efficacy of combining phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) and transvaginal ultrasound cervical length (CL) compared with either indicator alone in predicting pre-term labour (PTL). Women with singleton pregnancy between 24 and 36 weeks' gestation with evidence of PTL were subjected to phIGFBP-1 and CL tests. Of the 51 women, five were tested positive (phIGFBP-1 positive and CL <2.5 cm) for combination of phIGFBP-1 and CL (four delivered within 1 week), whereas 46 tested negative, of which, only one delivered. A much higher negative predictivity (NP), positive predictivity (PP) and specificity (SP) in the combination test was seen compared with phIGFBP-1 or CL alone (NP: 97.8% vs 97.7% vs 97.1%; PP: 80.0% vs 51.1% and CL 23.5%; SP: 97.8% vs 93.5% vs 71.1%, respectively). The cervical os dilatation of 2 cm with combined positive test (p = 0.001) indicated a higher likelihood of PTL.
这项前瞻性观察性研究旨在评估磷酸化胰岛素样生长因子结合蛋白-1（phIGFBP-1）与经阴道超声测量宫颈长度（CL）联合使用相较于单独使用任一指标预测早产（PTL）的效果。对妊娠24至36周、有早产迹象的单胎妊娠女性进行phIGFBP-1和CL检测。在51名女性中，phIGFBP-1和CL联合检测呈阳性（phIGFBP-1阳性且CL<2.5 cm）的有5名（4名在1周内分娩），而46名检测为阴性，其中只有1名分娩。与单独使用phIGFBP-1或CL相比，联合检测的阴性预测值（NP）、阳性预测值（PP）和特异性（SP）更高（NP：97.8%对97.7%对97.1%；PP：80.0%对51.1%和CL 23.5%；SP：97.8%对93.5%对71.1%）。联合检测呈阳性时宫颈口扩张2 cm（p = 0.001）表明早产的可能性更高。
