ErbB 受体和脂肪酸合酶在侵袭性头颈部鳞状细胞癌中的表达。

ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.

机构信息

Department of Head and Neck Surgery and Otorhinolaryngology Anatomic Pathology Thoracic Surgery, A.C. Camargo Hospital, São Paulo, Brazil.

出版信息

Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.

DOI:10.1111/j.1601-0825.2010.01687.x

PMID:20604875

Abstract

SUMMARY

Overexpression of ErbB receptors is frequent in head and neck squamous cell carcinomas (HNSCC) and seems to be correlated with tumor progression and metastasis. Fatty acid synthase (FASN), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, is regulated by ErbB2 and overexpressed in several human malignancies.

METHODS

This study was performed to examine the immunohistochemical expression patterns of ErbB1, ErbB2, ErbB3, ErbB4, and FASN in a tissue microarray, containing 33 representative areas from aggressive primary HNSCC (whose patients had distant metastasis), and 21 matched lung metastasis.

RESULTS

Strong correlation among the expression of ErbB family receptors was found (ErbB1-ErbB2 P = 0.008, ErbB1-ErbB4 P = 0.018, EbB2-ErbB3 P = 0.001, ErbB2-ErbB4 P = 0.006, ErbB3-ErbB4 P=0.012) in the HNSCC. FASN expression was significantly associated with ErbB2 (P = 0.024). Lymphatic permeation was correlated with ErbB3 (P = 0.033) and histological grade with ErbB4 staining (P = 0.050). ErbB1 and ErbB2 were found mainly in patients with smoking habit (P = 0.011 and P = 0.027), and ErbB2 was associated with alcohol consumption and clinical stage (P = 0.014 and P = 0.031). Finally, FASN was overexpressed in lung metastasis, in comparison with matched HNSCC samples (P = 0.006).

CONCLUSIONS

The results showed that high FASN immunohistochemical expression is a feature of HNSCC lung metastasis, and ErbB1-ErbB2, ErbB1-ErbB4, ErbB2-ErbB3, ErbB2-ErbB4, and ErbB3-ErbB4 expression levels are correlated in the respective primary tumors, being ErbB2 the preferred coexpression partner of all the other ErbB receptors.

摘要

表皮生长因子受体（ErbB）家族受体在头颈部鳞状细胞癌（HNSCC）中经常过表达，似乎与肿瘤的进展和转移有关。脂肪酸合酶（FASN）是负责内源性脂肪酸合成的关键脂肪生成酶，它受 ErbB2 调节，并在几种人类恶性肿瘤中过度表达。

方法

本研究旨在通过免疫组织化学方法，在一个包含 33 个侵袭性原发性 HNSCC（其患者发生远处转移）和 21 个匹配的肺转移的组织微阵列中，检测 ErbB1、ErbB2、ErbB3、ErbB4 和 FASN 的表达模式。

结果

在 HNSCC 中，发现 ErbB 家族受体的表达之间存在强烈的相关性（ErbB1-ErbB2 P = 0.008，ErbB1-ErbB4 P = 0.018，ErbB2-ErbB3 P = 0.001，ErbB2-ErbB4 P = 0.006，ErbB3-ErbB4 P = 0.012）。FASN 的表达与 ErbB2 显著相关（P = 0.024）。淋巴渗透与 ErbB3 相关（P = 0.033），组织学分级与 ErbB4 染色相关（P = 0.050）。ErbB1 和 ErbB2 主要在有吸烟习惯的患者中发现（P = 0.011 和 P = 0.027），ErbB2 与酒精消耗和临床分期相关（P = 0.014 和 P = 0.031）。最后，与匹配的 HNSCC 样本相比，FASN 在肺转移中过度表达（P = 0.006）。