Piedras María José G M, García-Cabezas Miguel Ángel, Sendagorta Elena, Miró-Murillo Marta, Cavada Carmen
Department of Anatomy, Histology and Neuroscience, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Vet Dermatol. 2011 Apr;22(2):209-14. doi: 10.1111/j.1365-3164.2010.00915.x.
A case of psoriasiform dermatitis in an adult male rhesus macaque is reported. Appearing spontaneously, the condition presented the clinical and histopathological features of human palmoplantar nonpustular psoriasis. The animal developed multiple scaly plaques on his palms and soles, as well as nail hyperkeratosis and widening of the nail root. Microscopically, the skin lesions showed epidermal hyperkeratosis with multifocal parakeratosis, neutrophil microabscesses in the stratum corneum, a loss of granule cell layer under the microabscesses, acanthosis, and elongation of the rete ridges; the superficial dermis showed a dense inflammatory infiltrate containing lymphocytes, macrophages and neutrophils, as well as dilated and tortuous blood vessels. The lesions improved for 15 days after intramuscular corticosteroid depot therapy and worsened slightly afterwards. Later, a spontaneous, progressive remission coincided with the beginning of spring and lasted until the end of summer; the skin lesions practically disappeared during this period, and the nails looked nearly normal. During the next autumn and winter only nail hyperkeratosis was present. Serum analyses showed hyperproteinaemia and hyperglobulinaemia during the outbreak phase and normal values during remission. The clinical and histopathological features of this case, as well as its evolution, are compared with the three other reported cases of psoriasiform skin lesions in nonhuman primates. To the authors' knowledge, this is the first report of a definite palmoplantar nonpustular psoriasiform dermatitis in a rhesus macaque.
报告了一例成年雄性恒河猴的银屑病样皮炎病例。该病症自发出现，呈现出人类掌跖非脓疱型银屑病的临床和组织病理学特征。这只动物的手掌和脚底出现了多个鳞屑性斑块，同时伴有指甲角化过度和甲根增宽。显微镜下，皮肤病变表现为表皮角化过度伴多灶性角化不全、角质层中性粒细胞微脓肿、微脓肿下方颗粒细胞层缺失、棘层肥厚和 rete 嵴延长；浅表真皮显示有密集的炎症浸润，包含淋巴细胞、巨噬细胞和中性粒细胞，以及扩张和迂曲的血管。肌肉注射长效皮质类固醇治疗后，病变改善了 15 天，之后略有恶化。后来，随着春季开始出现自发的、进行性缓解，并持续到夏末；在此期间皮肤病变几乎消失，指甲看起来接近正常。在接下来的秋冬季节，仅存在指甲角化过度。血清分析显示在发病期有高蛋白血症和高球蛋白血症，缓解期各项指标正常。将该病例的临床和组织病理学特征及其演变与其他三例已报道的非人灵长类动物银屑病样皮肤病变病例进行了比较。据作者所知，这是恒河猴中明确的掌跖非脓疱型银屑病样皮炎的首例报告。
