Tagliavini S, Genedani S, Bertolini A, Bazzani C
Institute of Pharmacology, University of Modena, Italy.
Eur J Pharmacol. 1991 Feb 26;194(1):7-10. doi: 10.1016/0014-2999(91)90116-8.
The influence of putrescine on cardiac arrhythmias induced by either permanent ligature of the left anterior coronary artery or heart reperfusion following a 5-min coronary occlusion was studied in anesthetized rats. Reperfusion-induced arrhythmias were significantly prevented by the i.v. injection of 150-200 mg/kg of putrescine, the survival rate being 100% in treated animals and 40% in controls. At a dose level of 200-300 mg/kg i.v., putrescine also significantly reduced the duration of ventricular tachycardia induced by permanent coronary occlusion. These findings show that putrescine significantly reduces the consequences of cardiac ischemia and reperfusion, probably as a consequence of its multiple stabilizing effects at the membrane level.
在麻醉大鼠中，研究了腐胺对由左冠状动脉永久结扎或冠状动脉闭塞5分钟后心脏再灌注所诱发的心律失常的影响。静脉注射150 - 200mg/kg腐胺可显著预防再灌注诱发的心律失常，治疗组动物的存活率为100%，而对照组为40%。静脉注射剂量为200 - 300mg/kg时，腐胺还可显著缩短永久冠状动脉闭塞诱发的室性心动过速的持续时间。这些发现表明，腐胺可显著减轻心脏缺血和再灌注的后果，这可能是其在膜水平上具有多种稳定作用的结果。
