老年人带状疱疹疫苗：增强免疫力。
Herpes zoster vaccine for the elderly: boosting immunity.
作者信息
Chua Joel V, Chen Wilbur H
机构信息
Division of Infectious Disease, University of Maryland School of Medicine, MD, USA, Tel.: +1 410 328 5039.
出版信息
Aging health. 2010 Apr 1;6(2):169-176. doi: 10.2217/ahe.10.5.
Herpes zoster, also known as shingles, is a disease that results from the reactivation of a latent infection of the varicella zoster virus, which is usually encountered during early childhood. Aging is associated with an increased risk for herpes zoster and its complications. Boosting immunological memory is the key strategy for keeping the latent varicella zoster virus infection under control. A live attenuated virus vaccine is safe, effective and approved for use among healthy elderly adults aged 60 years or older. However, significant problems remain in the prevention of herpes zoster with the current vaccine. Future studies for improved vaccines and studies into the epidemiology of herpes zoster are required in order to address this significant public health burden.
带状疱疹，又称蛇串疮，是由水痘-带状疱疹病毒潜伏感染再激活引起的疾病，这种病毒通常在儿童早期感染。年龄增长与带状疱疹及其并发症的风险增加有关。增强免疫记忆是控制水痘-带状疱疹病毒潜伏感染的关键策略。一种减毒活病毒疫苗安全有效，已被批准用于60岁及以上的健康老年人。然而，目前的疫苗在预防带状疱疹方面仍存在重大问题。为了解决这一重大公共卫生负担，需要开展改进疫苗的未来研究以及带状疱疹流行病学研究。
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