Department of Human Morphology and Developmental Biology, Semmelweis University, Tűzoltó u. 58, Budapest H-1094, Hungary.
J Mol Neurosci. 2011 Jan;43(1):109-14. doi: 10.1007/s12031-010-9408-z. Epub 2010 Jul 6.
It was previously demonstrated that secretin influenced the behavior of rats investigated by open-field test. In the present experiment, we have compared the effect of intracerebroventricular administration of 2 μg of secretin on the behavior of CFLP white and Japanese waltzing mice. These latter animals exhibit stereotypic circular movements. The effect of secretin on the horizontal (ambulation) and vertical movements (rearing and jumping) was investigated in open-field test. The ambulation time and distance were shorter, and the number of rearing and jumping were much lower in Japanese waltzing mice than in CFLP white mice during 30 min-experimental period. In white mice, 2 μg of secretin had no effect on the above-mentioned parameters; however, in Japanese waltzing mice, secretin enhanced the ambulation time and distance to the level of CFLP white mice, but did not influence the rearing and jumping. On the basis of the results, it was concluded that intracerebroventricularly administered secretin attenuated the stereotypic (circulating) movement and improved the horizontal movement indicated by the normalization of the ambulation time and distance; however, it did not influence the explorative behavior (rearing and jumping) in our special animal model.
先前的研究表明，分泌素会影响大鼠在旷场实验中的行为。在本实验中，我们比较了脑室注射 2μg 分泌素对 CFLP 白化鼠和日本摇摆鼠行为的影响。后两种动物表现出刻板的圆形运动。在旷场实验中，我们研究了分泌素对水平（走动）和垂直运动（站立和跳跃）的影响。在 30 分钟的实验期间，日本摇摆鼠的走动时间和距离更短，站立和跳跃次数也远低于 CFLP 白化鼠。在白化鼠中，2μg 的分泌素对上述参数没有影响；然而，在日本摇摆鼠中，分泌素增强了走动的时间和距离，使其达到 CFLP 白化鼠的水平，但对站立和跳跃没有影响。基于这些结果，我们得出结论，脑室注射的分泌素减轻了刻板的（循环）运动，并通过走动时间和距离的正常化改善了水平运动；然而，它并没有影响我们特殊动物模型中的探索行为（站立和跳跃）。
