Veenendaal R A, Peeters A J, Kreuning J, Peña S, Gooszen H G, Lamers C B
Department of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
Gastroenterol Clin Biol. 1991;15(4):355-7.
In one patient, upper abdominal symptoms developed 6 months after the start of diclofenac. At upper gastrointestinal endoscopy duodenal stenosis was shown next to a large diverticulum containing non-dissolved tablets in the third part of the duodenum. As there was no improvement with medical treatment, resection of the diverticulum and stenosis with primary end-to-end anastomosis was performed. Apart from persistent activity of rheumatoid arthritis the patient has been well since. The possible gastrointestinal side-effects of nonsteroidal antiinflammatory drugs in patients with duodenal diverticula are discussed.
在一名患者中，双氯芬酸开始使用6个月后出现上腹部症状。上消化道内镜检查显示十二指肠狭窄，紧邻十二指肠第三段一个含有未溶解药片的大憩室。由于药物治疗无效，遂行憩室和狭窄切除术并进行一期端端吻合术。此后，除类风湿关节炎持续活动外，患者情况良好。文中讨论了十二指肠憩室患者使用非甾体抗炎药可能出现的胃肠道副作用。
