鸡 NKX2.8 同源盒基因：NK-2 基因家族的一个新成员。

The chicken NKX2.8 homeobox gene: A novel member of the NK-2 gene family.

机构信息

Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-37077 Göttingen, Germany, , , , , , DE.

出版信息

Dev Genes Evol. 1997 May;207(1):65-70. doi: 10.1007/s004270050092.

PMID:20607481

Abstract

We have isolated the chicken homeobox gene NKX2.8, which represents a novel member of the NK-2 gene family. Besides the homeodomain, the NKX2.8 protein contains two other conserved sequences, a TN and an NK2 domain. NKX2.8 is expressed in the ventral foregut, the developing heart, in the epithelial layers of the branchial arches and in the dorsal mesocardium. Thus, its expression overlaps partially, but also differs significantly from another chicken tinman orthologue, the NKX2.5 gene. It is suggestive that NKX2.8 and NKX2.5 play a cooperative role in early heart development.

摘要

我们已经分离出鸡同源盒基因 NKX2.8，它代表 NK-2 基因家族的一个新成员。除了同源域，NKX2.8 蛋白还包含另外两个保守序列，一个 TN 和一个 NK2 结构域。NKX2.8 在腹侧前肠、正在发育的心脏、鳃弓的上皮层和背侧心脏中表达。因此，它的表达部分重叠，但也与另一个鸡 tinman 同源物 NKX2.5 基因有显著差异。这表明 NKX2.8 和 NKX2.5 在早期心脏发育中发挥协同作用。