Chemistry Department, Menoufia University, Shebin El-Kom, Egypt.
Arch Pharm Res. 2010 Jun;33(6):797-805. doi: 10.1007/s12272-010-0601-y. Epub 2010 Jul 6.
A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities.
一些 N-和 S-取代的尿嘧啶和硫代尿嘧啶糖苷通过 5,6-二苄基嘧啶衍生物与相应的乙酰溴代糖的偶联反应合成。合成的化合物进行了抗乙型肝炎病毒的抗病毒活性测试。噬斑减少感染性测定法用于测定由于用测试化合物处理而导致的病毒数量减少，结果表明这些化合物具有中等至高度的抗病毒活性。
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