从仙茅中分离得到的三个新的酚苷
Three new phenolic glycosides from Curculigo orchioides G.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
出版信息
Fitoterapia. 2010 Oct;81(7):910-3. doi: 10.1016/j.fitote.2010.06.003. Epub 2010 Jun 13.
Three new phenolic glycosides, curculigosides F-H (1-3), were isolated from rhizomes of Curculigo orchioides Gaertn. Their structures were elucidated based on comprehensive spectroscopic analyses including IR, MS, 1D- and 2D NMR (HSQC, COSY, and HMBC). Curculigosides F-H (1-3) were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compound 1 exhibited weak activity with an IC(50) value of 2.08 mM on hepatitis B virus (HBV) e antigen (HBeAg) secretion of the HepG2.2.15 cell line.
从莪术 Curculigo orchioides Gaertn 的根茎中分离得到三个新的酚糖苷，即 curculigosides F-H（1-3）。基于包括 IR、MS、1D 和 2D NMR（HSQC、COSY 和 HMBC）在内的综合光谱分析，阐明了它们的结构。使用 HBV 转染的 Hep G2.2.15 细胞系，评估了 curculigosides F-H（1-3）在体外的抗 HBV 活性。化合物 1 对 HepG2.2.15 细胞系 HBV e 抗原（HBeAg）分泌的 IC50 值为 2.08 mM，表现出较弱的活性。
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