Kunming Institute of Precious Metals, 650106, Kunming, China.
Arch Pharm Res. 2010 Jun;33(6):807-11. doi: 10.1007/s12272-010-0602-x. Epub 2010 Jul 6.
A novel mixed NH(3)/NH(2)OH platinum(II) complex cis-[Pt(NH(3))(NH(2)OH)Cl(2)] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and (1)H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.
一种新型的混合 NH(3)/NH(2)OH 铂(II)配合物顺式-[Pt(NH(3))(NH(2)OH)Cl(2)]被合成并通过元素分析、FAB-MS、FT-IR 和 (1)H NMR 光谱进行了表征。该配合物具有良好的水溶性和令人满意的稳定性。评估了相关配合物对 3AO、HCT-116、LNcap、A549/ATCC 和 SGC-7901 人癌细胞系的体外细胞毒性。它表现出可观的细胞毒性活性，与顺铂相当，比卡铂更有效。
