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造血细胞移植患者应用高剂量阿昔洛韦持续输注治疗阿昔洛韦耐药单纯疱疹病毒。

Treatment of acyclovir-resistant herpes simplex virus with continuous infusion of high-dose acyclovir in hematopoietic cell transplant patients.

机构信息

Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

出版信息

Biol Blood Marrow Transplant. 2011 Feb;17(2):259-64. doi: 10.1016/j.bbmt.2010.06.020. Epub 2010 Jul 6.

DOI:10.1016/j.bbmt.2010.06.020
PMID:20615475
Abstract

Infection because of herpes simplex virus (HSV) that is resistant to acyclovir (ACV) poses treatment challenges in hematopoietic cell transplant (HCT) patients. We present a series of patients with ACV-resistant HSV following HCT who were successfully treated with continuous infusion high-dose ACV after failing standard treatment regimens for ACV-resistant HSV.

摘要

由于单纯疱疹病毒（HSV）对阿昔洛韦（ACV）耐药而导致的感染，给造血细胞移植（HCT）患者的治疗带来了挑战。我们报告了一系列 HCT 后出现 ACV 耐药 HSV 的患者，他们在标准 ACV 耐药 HSV 治疗方案失败后，通过接受连续输注高剂量 ACV 治疗而获得成功。

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