Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan. m-kudo @ med.kindai.ac.jp
Oncology. 2010 Jul;78 Suppl 1:40-5. doi: 10.1159/000315229. Epub 2010 Jul 8.
The aim of this study is to clarify the usefulness of defect reperfusion ultrasound (US) imaging using Sonazoid in the management of hepatocellular carcinoma (HCC). A total of 33 HCC nodules and 34 local recurring nodules after radiofrequency ablation (RFA), which could not be identified by B-mode US but were depicted by dynamic CT, were studied by defect reperfusion US imaging with Sonazoid. In addition, Kupffer phase Sonazoid-enhanced US in combination with defect reperfusion US imaging were used for screening HCC in 262 consecutive cirrhotic patients. As a result, 33 US undetectable HCC nodules and 34 local recurring HCC nodules were successfully confirmed by Sonazoid-enhanced US with defect reperfusion imaging. Subsequently, RFA was successfully performed in all of 67 HCC nodules with a Sonazoid-enhanced US guidance. A total of 7 small HCCs were depicted and confirmed as HCCs by Kupffer phase surveillance and defect reperfusion US imaging. In conclusion, defect reperfusion US imaging is extremely useful in the depiction and confirmation of US undetectable HCCs as well as in the surveillance of HCC in cirrhotic patients.
本研究旨在阐明使用声诺维（ SonoVue ）进行缺陷再灌注超声（ US ）成像在肝细胞癌（ HCC ）管理中的作用。共研究了 33 个 HCC 结节和 34 个射频消融（ RFA ）后的局部复发性结节，这些结节在 B 型 US 下无法识别，但在动态 CT 下显示。通过 Sonazoid 进行缺陷再灌注 US 成像来研究。此外，在 262 例连续肝硬化患者中，使用 Sonazoid 增强 US 结合缺陷再灌注 US 成像进行 HCC 筛查。结果，通过 Sonazoid 增强 US 缺陷再灌注成像成功确认了 33 个 US 无法检测到的 HCC 结节和 34 个局部复发性 HCC 结节。随后，在 Sonazoid 增强 US 引导下成功对 67 个 HCC 结节进行了 RFA 治疗。总共描绘和确认了 7 个小 HCC ，并通过枯否细胞期监测和缺陷再灌注 US 成像确认它们为 HCC 。总之，缺陷再灌注 US 成像对于描绘和确认 US 无法检测到的 HCC 以及监测肝硬化患者中的 HCC 非常有用。
