Ohshima K, Shen D T, Henson J B, Gorham J R
Am J Vet Res. 1978 Apr;39(4):653-7.
Gross and microscopic lesions of Aleutian disease (AD) in mink and hypergammaglobulinemia in ferrets were compared. Both conditions were characterized by widespread proliferation of plasma cells, but proliferation was more prominent in mink infected with AD. Arteritis did not occur in hypergammaglobulinemic ferrets. Minimal or no glomerular alterations occurred in infected ferrets, but were severe in mink infected with AD. Bile duct proliferation was more prominent in diseased mink. Tissue alterations suggested that AD in Aleutian genotype mink is more rapidly progressive than is AD in ferrets, causing overt clinical disease and death. In contrast, hypergammaglobulinemia in ferrets appeared to progress more slowly, with little clinical evidence of disease. This is probably the result of a paucity of glomerular lesions in ferrets. Possible mechanisms to explain the differences in the development of lesions are discussed.
对水貂阿留申病（AD）的大体和微观病变与雪貂高球蛋白血症进行了比较。两种病症均以浆细胞广泛增殖为特征，但在感染AD的水貂中增殖更为显著。高球蛋白血症雪貂未发生动脉炎。感染的雪貂肾小球改变轻微或无改变，但感染AD的水貂肾小球改变严重。患病水貂的胆管增殖更为显著。组织学改变表明，阿留申基因型水貂的AD比雪貂的AD进展更快，会导致明显的临床疾病和死亡。相比之下，雪貂的高球蛋白血症似乎进展较慢，几乎没有疾病的临床证据。这可能是雪貂肾小球病变较少的结果。文中讨论了解释病变发展差异的可能机制。
